04714nam a22006375i 4500 978-3-031-62131-4 DE-He213 20251030112842.0 cr nn 008mamaa 240808s2024 sz | s |||| 0|eng d 9783031621314 978-3-031-62131-4 10.1007/978-3-031-62131-4 doi QH573-671 QP82.2.S8 PSF bicssc SCI017000 bisacsh PSF thema Oxidative Stress in Cardiovascular-Metabolic Diseases [electronic resource] / edited by Ali Hussein Eid, Firas Kobeissy, Ahmed F. El-Yazbi. 1st ed. 2024. Cham : Springer Nature Switzerland : Imprint: Springer, 2024. XII, 298 p. 39 illus., 38 illus. in color. online resource. text txt rdacontent computer c rdamedia online resource cr rdacarrier text file PDF rda Oxidative Stress in Applied Basic Research and Clinical Practice, 2197-7232 Chapter 1 - Interplay between ROS and gender in the pathogenesis of cardiovascular disease -- chapter 2 -ROS, aging and cardiovascular disease -- Chapter 3 - Combat ROS, prevent CVD -- Chapter 4 -Traumatic-brain injury and CVD: ROS is the link? -- Chapter 5 - Adipose tissue inflammation and CVD: oxidative stress as a catalyst -- Chapter 6 - Oxidative stress in diabetes-compounded CVD -- Chapter 7 - ROS in hypertension: a critical update -- Chapter 8 - ROS in atherosclerosis: what we know.-Chapter 9 - ROS as a key mediator of cardiovasculometabolic disease -- Chapter 10 - Antioxidant Therapy in CVD: hope or hype? -- Chapter 11 - Antioxidants as adjuvant therapy: Evidence from clinical trials. The book dissects the role of oxidative stress in the pathogenesis of the leading causes of global morbidity and mortality, i.e.cardiovascular and metabolic diseases. The chapters discuss topics related to the role reactive oxygen species (ROS) play in hypertension, atherosclerosis,diabetes, obesity and related pathologies. The authors also shed light on gender differences in the onset and pathologies of some of these diseases. Moreover, how ROS and aging interplay to precipitate cardiovasculo-metabolic disease is discussed and highlighted. Preventive measures that can abrogate ROS-induced cardiovasclo-metabolic disease are discussed and clarified in the hope of reducing such a debilitating battery of diseases. A section dedicated to antioxidants as potential therapy is also included. Furthermore, given the complexity of the mechanisms implicated in ROS-modulated responses, it remains challenging to assert a conclusive argument and pre-determined regimen for incorporating antioxidants into conventional therapies. Nonetheless, results from some clinical trials appear promising, warranting the addition of a chapter dedicated to such human trials. In all of the chapters, the molecular, cellular, genetic, and pharmacological mechanisms implicated are covered from an applied science perspective. This is an ideal book for basic researchers in the biomedical field, graduate students in biological and biomedical fields, medical students, instructors in medical and graduate schools, and professionals working for pharmaceutical companies. Cytology. 67436 Stress (Physiology). 70794 Cardiovascular system. 75583 Physiology. 72764 Metabolism. 2468 Molecular biology. Cellular Stress. 82055 Cell Biology. 67440 Cardiovascular Physiology. 75584 Metabolism. 2468 Molecular Biology. Eid, Ali Hussein. editor. edt http://id.loc.gov/vocabulary/relators/edt 82056 Kobeissy, Firas. editor. edt http://id.loc.gov/vocabulary/relators/edt 79559 El-Yazbi, Ahmed F. editor. edt http://id.loc.gov/vocabulary/relators/edt 82057 SpringerLink (Online service) Springer Nature eBook Printed edition: 9783031621307 Printed edition: 9783031621321 Printed edition: 9783031621338 Oxidative Stress in Applied Basic Research and Clinical Practice, 2197-7232 82058 https://doi.org/10.1007/978-3-031-62131-4 ZDB-2-SBL ZDB-2-SXB 62314 62314