Eid, Ali Hussein. editor. edt http://id.loc.gov/vocabulary/relators/edt Kobeissy, Firas. editor. edt http://id.loc.gov/vocabulary/relators/edt El-Yazbi, Ahmed F. editor. edt http://id.loc.gov/vocabulary/relators/edt SpringerLink (Online service) text sz 2024 1st ed. 2024. monographic eng

electronic

electronic resource

access XII, 298 p. 39 illus., 38 illus. in color. online resource. The book dissects the role of oxidative stress in the pathogenesis of the leading causes of global morbidity and mortality, i.e.cardiovascular and metabolic diseases. The chapters discuss topics related to the role reactive oxygen species (ROS) play in hypertension, atherosclerosis,diabetes, obesity and related pathologies. The authors also shed light on gender differences in the onset and pathologies of some of these diseases. Moreover, how ROS and aging interplay to precipitate cardiovasculo-metabolic disease is discussed and highlighted. Preventive measures that can abrogate ROS-induced cardiovasclo-metabolic disease are discussed and clarified in the hope of reducing such a debilitating battery of diseases. A section dedicated to antioxidants as potential therapy is also included. Furthermore, given the complexity of the mechanisms implicated in ROS-modulated responses, it remains challenging to assert a conclusive argument and pre-determined regimen for incorporating antioxidants into conventional therapies. Nonetheless, results from some clinical trials appear promising, warranting the addition of a chapter dedicated to such human trials. In all of the chapters, the molecular, cellular, genetic, and pharmacological mechanisms implicated are covered from an applied science perspective. This is an ideal book for basic researchers in the biomedical field, graduate students in biological and biomedical fields, medical students, instructors in medical and graduate schools, and professionals working for pharmaceutical companies. Chapter 1 - Interplay between ROS and gender in the pathogenesis of cardiovascular disease -- chapter 2 -ROS, aging and cardiovascular disease -- Chapter 3 - Combat ROS, prevent CVD -- Chapter 4 -Traumatic-brain injury and CVD: ROS is the link? -- Chapter 5 - Adipose tissue inflammation and CVD: oxidative stress as a catalyst -- Chapter 6 - Oxidative stress in diabetes-compounded CVD -- Chapter 7 - ROS in hypertension: a critical update -- Chapter 8 - ROS in atherosclerosis: what we know.-Chapter 9 - ROS as a key mediator of cardiovasculometabolic disease -- Chapter 10 - Antioxidant Therapy in CVD: hope or hype? -- Chapter 11 - Antioxidants as adjuvant therapy: Evidence from clinical trials. edited by Ali Hussein Eid, Firas Kobeissy, Ahmed F. El-Yazbi. Cytology Stress (Physiology) Cardiovascular system Physiology Metabolism Molecular biology Cellular Stress Cell Biology Cardiovascular Physiology Metabolism Molecular Biology QH573-671 QP82.2.S8 9783031621314 https://doi.org/10.1007/978-3-031-62131-4 https://doi.org/10.1007/978-3-031-62131-4 240808 20251030112842.0 978-3-031-62131-4