04996nam a22005895i 4500001001800000003000900018005001700027007001500044008004100059020003700100024003500137050001000172050001400182072001600196072001700212072002300229072001500252072001600267245014300283250001800426264007200444300006600516336002600582337002600608338003600634347002400670505125100694520176801945650002203713650003703735650002503772650002303797650003103820650003003851650002203881650002203903650003503925650002503960650002303985650003204008650002204040700008504062710003404147773002604181776003604207776003604243776003604279856004604315912001404361912001404375999001704389978-981-97-4288-2DE-He21320251030112851.0cr nn 008mamaa240812s2024    si |    s    |||| 0|eng d  a97898197428829978-981-97-4288-27 a10.1007/978-981-97-4288-22doi 4aQH521 4aQD415-436 7aPSB2bicssc 7aMFGM2bicssc 7aSCI0130402bisacsh 7aPSB2thema 7aMFGM2thema10aAltered Metabolism: A Major Contributor of Comorbidities in Neurodegenerative Diseasesh[electronic resource] /cedited by Namita Agrawal.  a1st ed. 2024. 1aSingapore :bSpringer Nature Singapore :bImprint: Springer,c2024.  aXIII, 438 p. 60 illus., 43 illus. in color.bonline resource.  atextbtxt2rdacontent  acomputerbc2rdamedia  aonline resourcebcr2rdacarrier  atext filebPDF2rda0 aChapter 1: An Overview of Neurodegenerative Disorders -- Chapter 2: Mechanism underlying major neurodegenerative disorders -- Chapter 3: Involvement of metabolic paradigm in progression of neurodegenerative diseases -- Chapter 4: Glial cell metabolism and neurodegenerative diseases: The current perspective -- Chapter 5: Altered glucose homeostasis in neurological disorders -- Chapter 6: Lipid Metabolism: Key Determinant in Neurodegenerative Diseases -- Chapter 7 - Dysregulated peripheral metabolism in neurodegenerative disorders -- Chapter 8- Protein Metabolism: Critical factors implicated in neurodegenerative diseases -- Chapter 9 - Altered RNA metabolism in neurodegenerative disorders -- Chapter 10: Unveiling RNA dysfunction: A key player in neurodegeneration -- Chapter 11: Emerging Relationship between the Gut Microbiota and Neurodegenerative Disorders -- Chapter 12- Signaling Pathways in Neurodegenerative diseases -- Chapter 13: An overview of imaging techniques for diagnosis of debilitating neurodegenerative diseases -- Chapter 14: Novel Metabolic Biomarkers and Therapeutic Strategies in Neurodegenerative Diseases -- Chapter 15: Phytochemicals: Promising alternatives for metabolic regulation in neurodegenerative diseases.  aThis book presents a systematic and extensive understanding about metabolic alterations affecting multiple aspects of different neurodegenerative diseases (NDDs), such as Alzheimer’s, Parkinson’s, Huntington’s disease, SCAs, SBMA, DRPLA, ALS, Freidrich Ataxia etc. The book also illustrates cellular and molecular mechanisms behind the key neurodegenerative diseases and further expands on concept of unique and developing biomarkers associated with the onset and progression of NDDs. Additionally, it elaborates on the concept of latest imaging tools to monitor state of NDDs and accordingly develop therapeutic approaches entailing phytochemicals in the management of metabolic alterations associated with NDDs that ultimately suppresses course of devastating NDDs. The book aids to improve the overall understanding about the NDD and involvement of metabolic disorder as a major factor for indisposition of the disease. Therefore, suggesting that targetting metabolic variations by phytochemicals can combat NDD related symptoms for the betterment of impacted patients. While introducing cellular and molecular mechanisms and the treatment regimen under the umbrella of metabolism in several NDDs, the book covers major aspects of understanding the metabolic basis of NDDs, its implications, and treatment. This will inflate the readers' understanding about this particular area and guide those working in this domain, be it a researcher or clinicians,to choose or design effective therapeutic strategies to curb metabolic alterations linked with these disorders. This book will not only contribute towards improving the overall state of the challenged individuals but will also bring new hope towards improving the quality of lives of affected patients. 0aMetabolism.92468 0aNervous systemxDiseases.964036 0aTherapeutics.970087 0aInternal medicine. 0aMedicinexResearch.962598 0aBiologyxResearch.965629 0aNatural products.14aMetabolism.9246824aNeurological Disorders.97404224aTherapeutics.97008724aInternal Medicine.24aBiomedical Research.96563324aNatural Products.1 aAgrawal, Namita.eeditor.4edt4http://id.loc.gov/vocabulary/relators/edt9822632 aSpringerLink (Online service)0 tSpringer Nature eBook08iPrinted edition:z978981974287508iPrinted edition:z978981974289908iPrinted edition:z978981974290540uhttps://doi.org/10.1007/978-981-97-4288-2  aZDB-2-SBL  aZDB-2-SXB  c62421d62421