04273nam a22004095i 4500001001800000003000900018005001700027007001500044008004100059020001800100024003500118050000700153072001500160072002300175072001400198100008100212245018000293250001800473264006900491300006400560336002600624337002600650338003600676347002400712505078300736520203701519650001403556650003303570650002303603650002303626710003403649773002603683776003603709776003603745776003603781856004603817978-3-031-58380-3DE-He21320251030112901.0cr nn 008mamaa240821s2024    sz |    s    |||| 0|eng d  a97830315838037 a10.1007/978-3-031-58380-32doi 4aR1 7aMB2bicssc 7aMED0000002bisacsh 7aMB2thema1 aFabricant, Peter D.eauthor.4aut4http://id.loc.gov/vocabulary/relators/aut10aPractical Clinical Research Design and Applicationh[electronic resource] :bA Primer for Physicians, Surgeons, and Clinical Healthcare Professionals /cby Peter D. Fabricant.  a1st ed. 2024. 1aCham :bSpringer Nature Switzerland :bImprint: Springer,c2024.  aXV, 118 p. 37 illus., 15 illus. in color.bonline resource.  atextbtxt2rdacontent  acomputerbc2rdamedia  aonline resourcebcr2rdacarrier  atext filebPDF2rda0 aPart I: Foundational Basics -- Descriptive Statistics -- Comparative Statistics: Categorical Data -- Comparative Statistics: Continuous Data -- Statistical Power and Power Calculations -- Characteristics of a Diagnostic Test: Sensitivity, Specificity, Positive Predictive Value, and Negative Predictive Value -- Statistical Bias -- The Iterative Process of Designing Successful Clinical Research -- Part II: Choosing and Executing an Appropriate Clinical Study Design -- Randomized Controlled Trials -- Case-Control Studies -- Cohort Studies -- Cross-Sectional Studies -- Case Series and Case Reports -- Part III: Specialized Study Designs -- Propensity Score Matched Studies -- Interrater and Intrarater Reliability Studies -- Clinical Outcome Scale Development and Validation.  aEvery practicing physician, surgeon, advanced practice provider, and allied health professional interacts regularly with peer-reviewed literature: either while creating it, or consuming it. Despite the countless hours over many years spent in formal clinical training, many clinicians and clinician-authors lack advanced training or a working nuanced knowledge of research methodology and study design. Institutions have responded to this gap by reinforcing their ranks with statistical and methodological support in the form of data analysts, epidemiologists, and biostatisticians. However, clinicians are often unable to “talk the methodological talk” to guide them. This ultimately results in a stark disconnect between clinically relevant aspects of research and appropriate study design. Existing research methodology texts are largely written by statisticians, epidemiologists, and other academic public health experts. These are not easily digestible by practicing clinicians who need practical knowledge of this content to design their own research or enhance their understanding of the medical literature. Furthermore, these texts are often too detailed or “in the weeds” with regard to mathematics and statistical mechanics. Practical knowledge is not centrally located; rather, it is spread out among multiple books, articles, and other sources. This book is a concise, accessible, and practical guide for clinicians to read and reference when designing and reviewing clinical research. It is designed to be a standalone text, written “by a clinician, for clinicians” by a practicing clinical research expert who has had advanced formal training in research methodology, biostatistics, and epidemiology. Topics covered include descriptive and comparative statistics, power and sample size calculations, diagnostic tests, bias, and study design. In each chapter, consideration is given to study mechanics, advantages and disadvantages of each design, and illustrative analytical reviews of existing literature. 0aMedicine. 0aClinical medicinexResearch.14aClinical Medicine.24aClinical Research.2 aSpringerLink (Online service)0 tSpringer Nature eBook08iPrinted edition:z978303158379708iPrinted edition:z978303158381008iPrinted edition:z978303158382740uhttps://doi.org/10.1007/978-3-031-58380-3