03961nam a22004695i 4500001001800000003000900018005001700027007001500044008004100059020001800100024003500118050001000153072001600163072002300179072001500202245018200217250001800399264006700417300006600484336002600550337002600576338003600602347002400638490005400662505112300716520111001839650001602949650002302965650001802988650001603006650002003022650001803042700007703060700008603137710003403223773002603257776003603283776003603319776003603355830005403391856004603445978-3-031-66421-2DE-He21320251030112929.0cr nn 008mamaa240901s2024    sz |    s    |||| 0|eng d  a97830316642127 a10.1007/978-3-031-66421-22doi 4aQH671 7aPSF2bicssc 7aSCI0170002bisacsh 7aPSF2thema10aRole of Autophagy and Reactive Oxygen Species in Cancer Treatmenth[electronic resource] :bPrinciples and Current Strategies /cedited by Neeraj Mishra, Ravinder Kumar Kaundal.  a1st ed. 2024. 1aCham :bSpringer Nature Switzerland :bImprint: Humana,c2024.  aVIII, 372 p. 54 illus., 53 illus. in color.bonline resource.  atextbtxt2rdacontent  acomputerbc2rdamedia  aonline resourcebcr2rdacarrier  atext filebPDF2rda1 aCancer Drug Discovery and Development,x2196-99140 aPreface -- Autophagy and Reactive Oxygen Species in Cancer: An Introduction -- Reactive Oxygen Species (ROS) and Cancer -- Unveiling Therapeutic Targets: Targeting Mitochondrial ROS for Anticancer Therapy -- Molecular Mechanisms of Autophagy Regulation in Cancer -- Autophagy and multi-drug resistance in cancer -- Interplay between Autophagy and Reactive Oxygen Species (ROS) -- Autophagy, Reactive Oxygen Species and Tumorigenesis -- Role of Autophagy and Oxidative Stress in Cancer Metastasis -- Autophagy-targeted Nanoparticles for the Treatment of Cancer -- Autophagy: A Critical Link between Immune Response and Cancer Progression -- Interplay between Autophagy and Apoptosis in Cancer: Mechanisms and Therapeutic Implications -- Unraveling the Nexus: Mitochondrial Oxidative Stress, Tumour Microenvironment, and Escape from Immune Surveillance -- Current Strategies for Targeting Autophagy and ROS for Cancer Treatment -- Exploring the Potential of Dietary Phytochemicals in Cancer Therapeutics: Modulating Apoptosis and Autophagy -- Clinical Trials and Future Prospects of Autophagy and ROS in Cancer -- Index.  aAutophagy is a catabolic process that eliminates damaged and faulty cellular components via lysosomes. It responds to adverse circumstances like nutritional deficiency, hypoxia, and oxidative damage. Reactive oxygen species (ROS) cause oxidative stress, which is a multidimensional chemical that drives various pathophysiological diseases, including cancer. In addition, the autophagy process has a double role, first preventing tumour formation, but later fostering tumour progression. A growing body of research suggests that autophagy and ROS have a complex interplay in which they can either prevent cancer growth or enhance disease genesis. While a combination of autophagy inhibitor and cytotoxic medicines is now being used in cancer treatment, investigating the potential of autophagy inhibitors for overcoming resistance to different anticancer medications and how this relates to the control of cancer micro environmental stressors raises several questions. Autophagy's dual functions as a safeguarding and cytotoxic process have drawn attention to its significance in the development of cancer. 0aCell death. 0aCancerxTreatment. 0aPharmacology.14aCell Death.24aCancer Therapy.24aPharmacology.1 aMishra, Neeraj.eeditor.4edt4http://id.loc.gov/vocabulary/relators/edt1 aKaundal, Ravinder Kumar.eeditor.4edt4http://id.loc.gov/vocabulary/relators/edt2 aSpringerLink (Online service)0 tSpringer Nature eBook08iPrinted edition:z978303166420508iPrinted edition:z978303166422908iPrinted edition:z9783031664236 0aCancer Drug Discovery and Development,x2196-991440uhttps://doi.org/10.1007/978-3-031-66421-2