04345nam a22005535i 4500 978-3-031-66421-2 DE-He213 20251030112929.0 cr nn 008mamaa 240901s2024 sz | s |||| 0|eng d 9783031664212 978-3-031-66421-2 10.1007/978-3-031-66421-2 doi QH671 PSF bicssc SCI017000 bisacsh PSF thema Role of Autophagy and Reactive Oxygen Species in Cancer Treatment [electronic resource] : Principles and Current Strategies / edited by Neeraj Mishra, Ravinder Kumar Kaundal. 1st ed. 2024. Cham : Springer Nature Switzerland : Imprint: Humana, 2024. VIII, 372 p. 54 illus., 53 illus. in color. online resource. text txt rdacontent computer c rdamedia online resource cr rdacarrier text file PDF rda Cancer Drug Discovery and Development, 2196-9914 Preface -- Autophagy and Reactive Oxygen Species in Cancer: An Introduction -- Reactive Oxygen Species (ROS) and Cancer -- Unveiling Therapeutic Targets: Targeting Mitochondrial ROS for Anticancer Therapy -- Molecular Mechanisms of Autophagy Regulation in Cancer -- Autophagy and multi-drug resistance in cancer -- Interplay between Autophagy and Reactive Oxygen Species (ROS) -- Autophagy, Reactive Oxygen Species and Tumorigenesis -- Role of Autophagy and Oxidative Stress in Cancer Metastasis -- Autophagy-targeted Nanoparticles for the Treatment of Cancer -- Autophagy: A Critical Link between Immune Response and Cancer Progression -- Interplay between Autophagy and Apoptosis in Cancer: Mechanisms and Therapeutic Implications -- Unraveling the Nexus: Mitochondrial Oxidative Stress, Tumour Microenvironment, and Escape from Immune Surveillance -- Current Strategies for Targeting Autophagy and ROS for Cancer Treatment -- Exploring the Potential of Dietary Phytochemicals in Cancer Therapeutics: Modulating Apoptosis and Autophagy -- Clinical Trials and Future Prospects of Autophagy and ROS in Cancer -- Index. Autophagy is a catabolic process that eliminates damaged and faulty cellular components via lysosomes. It responds to adverse circumstances like nutritional deficiency, hypoxia, and oxidative damage. Reactive oxygen species (ROS) cause oxidative stress, which is a multidimensional chemical that drives various pathophysiological diseases, including cancer. In addition, the autophagy process has a double role, first preventing tumour formation, but later fostering tumour progression. A growing body of research suggests that autophagy and ROS have a complex interplay in which they can either prevent cancer growth or enhance disease genesis. While a combination of autophagy inhibitor and cytotoxic medicines is now being used in cancer treatment, investigating the potential of autophagy inhibitors for overcoming resistance to different anticancer medications and how this relates to the control of cancer micro environmental stressors raises several questions. Autophagy's dual functions as a safeguarding and cytotoxic process have drawn attention to its significance in the development of cancer. Cell death. 83443 Cancer Treatment. 63722 Pharmacology. 67844 Cell Death. 83444 Cancer Therapy. 73414 Pharmacology. 67844 Mishra, Neeraj. editor. edt http://id.loc.gov/vocabulary/relators/edt 74463 Kaundal, Ravinder Kumar. editor. edt http://id.loc.gov/vocabulary/relators/edt 83445 SpringerLink (Online service) Springer Nature eBook Printed edition: 9783031664205 Printed edition: 9783031664229 Printed edition: 9783031664236 Cancer Drug Discovery and Development, 2196-9914 83446 https://doi.org/10.1007/978-3-031-66421-2 ZDB-2-SBL ZDB-2-SXB 62978 62978