03479nam a22004575i 4500001001800000003000900018005001700027007001500044008004100059020001800100024003500118050001400153072001600167072002300183072001500206245010800221250001800329264007500347300004200422336002600464337002600490338003600516347002400552490006100576505105100637520073301688650001802421650001902439650001802458650003302476700007902509700007902588700007902667710003402746773002602780776003602806776003602842776003602878830006102914856004602975978-3-031-66776-3DE-He21320251030112938.0cr nn 008mamaa240904s2024    sz |    s    |||| 0|eng d  a97830316677637 a10.1007/978-3-031-66776-32doi 4aRM300-666 7aMMG2bicssc 7aMED0710002bisacsh 7aMKG2thema10aAdrenoceptorsh[electronic resource] /cedited by Jillian G. Baker, Martin C. Michel, Roger J. Summers.  a1st ed. 2024. 1aCham :bSpringer International Publishing :bImprint: Springer,c2024.  aX, 688 p. 70 illus.bonline resource.  atextbtxt2rdacontent  acomputerbc2rdamedia  aonline resourcebcr2rdacarrier  atext filebPDF2rda1 aHandbook of Experimental Pharmacology,x1865-0325 ;v2850 aIntroduction: a short history of adrenoceptor research -- Structures of Adrenoceptors -- Genetic Variants of Adrenoceptors -- Adrenoceptors: Receptors, Ligands and Their Clinical Uses, Molecular Pharmacology and Assays -- Signalling of adrenoceptors: canonical pathways and new paradigms -- Presynaptic Adrenoceptors -- Roles of b-adrenoceptor subtypes and therapeutics in human cardiovascular disease:- heart failure, tachyarrhythmias and other cardiovascular disorders -- Adrenoceptors and Hypertension -- Adrenoceptors in the Lower Urinary Tract -- Asthma and COPD: A Focus on b-Agonists – Past, Present and Future -- Adrenoceptors in the Eye- Physiological and Pathophysiological Relevance -- Adrenoceptors: A Focus on Psychiatric Disorders and Their Treatments -- Locus Coeruleus and Noradrenergic Pharmacology in Neurodegenerative Disease -- Clinical use of adrenergic receptor ligands in acute care settings -- Adrenoceptor expression and function in the endocrine pancreas -- b-adrenoceptors in cancer: old players and new perspectives.  aAdrenoceptors have been at the forefront of physiological and pharmacological research for a century. They served as prototypes for rationale drug design as recognized by a Nobel Prize to Sir James Black and for the molecular understanding and structure of G protein-coupled receptors as recognized by a Nobel Prize to Brian Kobilka and Robert J. Lefkowitz. Drugs directly or indirectly targeting adrenoceptors have become guideline-recommended treatments for more than 30 human and various animal diseases. This volume assembles leading experts on various types of adrenoceptor research to provide concise insight into the current standing and future direction of uses of adrenoceptor-targeted drugs and research in this field. 0aPharmacology. 0aDrugsxDesign.14aPharmacology.24aStructure-Based Drug Design.1 aBaker, Jillian G.eeditor.4edt4http://id.loc.gov/vocabulary/relators/edt1 aMichel, Martin C.eeditor.4edt4http://id.loc.gov/vocabulary/relators/edt1 aSummers, Roger J.eeditor.4edt4http://id.loc.gov/vocabulary/relators/edt2 aSpringerLink (Online service)0 tSpringer Nature eBook08iPrinted edition:z978303166775608iPrinted edition:z978303166777008iPrinted edition:z9783031667787 0aHandbook of Experimental Pharmacology,x1865-0325 ;v28540uhttps://doi.org/10.1007/978-3-031-66776-3