04842nam a22006015i 4500 978-3-031-65986-7 DE-He213 20251030113034.0 cr nn 008mamaa 240911s2024 sz | s |||| 0|eng d 9783031659867 978-3-031-65986-7 10.1007/978-3-031-65986-7 doi QR180-189.5 MJCM bicssc MED044000 bisacsh MJCM thema Antimicrobial Resistance: Factors to Findings [electronic resource] : Omics and Systems Biology Approaches / edited by Vijay Soni, Ajay Suresh Akhade. 1st ed. 2024. Cham : Springer International Publishing : Imprint: Springer, 2024. XV, 454 p. 43 illus., 42 illus. in color. online resource. text txt rdacontent computer c rdamedia online resource cr rdacarrier text file PDF rda Antimicrobial resistance and factors -- Genomics as a tool to track global AMR -- Meta-transcriptomics to reveal mechanisms of drug action and resistance -- Use of proteomics to study bacterial virulence and AMR -- Metabolomics to understand bacterial and drug metabolism -- Microbiome and AMR: A One Health perspective -- Environmental reservoirs, genomic epidemiology, and mobile genetic elements -- Multiomics approach to control AMR -- Systems biology and AMR -- Host-directed omics approaches to control AMR -- Role of AI and Machine Learning in omics analysis of AMR evolution and surveillance -- Drug discovery and AMR treatments using an omics-based approach -- Future perspectives of omics-systems biology to control AMR: Recommendations and future directions. Antimicrobial resistance (AMR) is increasing globally at an incredible rate, and many infectious diseases have already reached an alarming stage of resistance to existing treatments. WHO reports that nearly1.27 million people currently die each year due to resistant infections, and AMR is projected to account for 10 million annual deaths globally by 2050. There is an urgent need for novel approaches to address this issue. Omics technologies are powerful research tools used extensively to study pathogen biology and the activity of microbial agents. These tools, paired with systems biology approaches, can provide novel insights into antimicrobial susceptibility and resistance, and aid in the development of new, more effective measures to combat resistant pathogens. This book provides a comprehensive overview of omics technologies to study pathogen biology, including proteomics, genomics, transcriptomics, metabolomics, and microbiome analysis, and the role of systems biology in developing strategies to combat resistant pathogens. It addresses environmental reservoirs and mobile genetic agents in AMR, host-pathogen interactions and physiology in the development of resistance, drug repurposing and development, and cutting-edge tools such as machine learning, AI for big data analysis, and genomic surveillance. The final section discusses future perspectives on omics-systems biology in AMR, and identifies opportunities for scientific collaboration in the global fight against antimicrobial resistance. This book serves as a comprehensive and accessible resource for researchers in academia and industry focused on immunology, drug development, biotechnology, and systems biology. Immunology. 69214 Immune response. 84055 Pathogenic microorganisms. 84056 Bioinformatics. 64050 Diseases Causes and theories of causation. 78871 Genomics. 64972 Immunology. 69214 Antimicrobial Responses. 84057 Computational and Systems Biology. 65974 Pathogenesis. 78872 Genomics. 64972 Soni, Vijay. editor. (orcid)0000-0002-3395-7429 https://orcid.org/0000-0002-3395-7429 edt http://id.loc.gov/vocabulary/relators/edt 84058 Akhade, Ajay Suresh. editor. (orcid)0000-0002-0803-2416 https://orcid.org/0000-0002-0803-2416 edt http://id.loc.gov/vocabulary/relators/edt 84059 SpringerLink (Online service) Springer Nature eBook Printed edition: 9783031659850 Printed edition: 9783031659874 Printed edition: 9783031659881 https://doi.org/10.1007/978-3-031-65986-7 ZDB-2-SBL ZDB-2-SXB 63262 63262