04177nam a22005415i 4500 978-3-031-67148-7 DE-He213 20251030113051.0 cr nn 008mamaa 240918s2024 sz | s |||| 0|eng d 9783031671487 978-3-031-67148-7 10.1007/978-3-031-67148-7 doi RC321-580 PSAN bicssc SCI089000 bisacsh PSAN thema GABAB Receptor [electronic resource] / edited by Giancarlo Colombo. 2nd ed. 2024. Cham : Springer International Publishing : Imprint: Humana, 2024. XX, 341 p. 77 illus., 45 illus. in color. online resource. text txt rdacontent computer c rdamedia online resource cr rdacarrier text file PDF rda The Receptors, 2524-6488 ; Section 1: Molecular Biology, Biochemistry, and Functioning of the GABAB Receptor -- GABAB Receptor: Molecular Organization, Function, and Alternative Drug Development by Targeting Protein-Protein Interactions -- GABAB Receptor Functioning: Focus on Allosteric Modulation -- Section 2: Pharmacology of Baclofen -- Historical Overview on Baclofen, the Only GABAB Receptor Agonist Approved and Available for Clinical Use -- Baclofen for the Treatment of Spasticity and Dystonia in Cerebral Palsy -- Baclofen for the Treatment of Cough -- Baclofen for the Treatment of Alcohol Use Disorder -- Baclofen Safety, Toxicity, Withdrawal, and Overdose -- Section 3: Chemistry and Pharmacology of Positive Allosteric Modulators -- Recent Advances on Chemistry of GABAB Receptor Allosteric Modulators -- GABAB Receptor Positive Allosteric Modulators: Novel Approaches for Drug Design and Discovery -- Recent Advances on GABAB Receptor Positive Allosteric Modulators as Potential Pharmacotherapies for Neuropsychiatric Disorders -- Recent Advances on GABAB Receptor Positive Allosteric Modulators as Potential Pharmacotherapies for Substance Use Disorder and Food Addiction -- Recent Advances on GABAB Receptor Positive Allosteric Modulators as Potential Pharmacotherapies for Alcohol Use Disorder -- Section 4: Miscellanea -- γ-Hydroxybutiric Acid: A GABAB/GHB Receptor Agonist with a Unique Neuropharmacological and Therapeutic Profile -- Naturally Occurring GABAB Receptor Ligands -- Norman G. Bowery: A Founding Father of the GABAB Receptor Research Field – Reflections on His Contribution. This new edition presents an up-to-date, comprehensive overview of the GABAB receptor system, including a particular focus on the most recent therapeutic applications and potential. This receptor system has been implicated in several diseases and disorders, including gastroesophageal reflux disease, epilepsy, mood disorders, depression, and alcohol and substance use disorder. The authors, leading researchers in the field, explore a number of approaches, including medicinal chemistry, molecular biology, physiology, and preclinical and clinical pharmacology. The new edition is completely reworked and updated, featuring the latest pharmacological advances on baclofen and positive allosteric modulators. Neurosciences. 68384 Neurology . 66816 Neuropharmacology. 78368 Neuroscience. 68386 Neurology. 66816 Neuropharmacology. 78368 Colombo, Giancarlo. editor. edt http://id.loc.gov/vocabulary/relators/edt 84586 SpringerLink (Online service) Springer Nature eBook Printed edition: 9783031671470 Printed edition: 9783031671494 Printed edition: 9783031671500 The Receptors, 2524-6488 ; 84587 https://doi.org/10.1007/978-3-031-67148-7 ZDB-2-SBL ZDB-2-SXB 63506 63506