03523nam a22005055i 4500 978-3-031-63164-1 DE-He213 20251030113107.0 cr nn 008mamaa 240927s2024 sz | s |||| 0|eng d 9783031631641 978-3-031-63164-1 10.1007/978-3-031-63164-1 doi TP1-1185 TDC bicssc SCI013060 bisacsh TDC thema Dispersity, Structure and Phase Changes of Proteins and Bio Agglomerates in Biotechnological Processes [electronic resource] / edited by Arno Kwade, Ingo Kampen. 1st ed. 2024. Cham : Springer Nature Switzerland : Imprint: Springer, 2024. IX, 547 p. 276 illus., 165 illus. in color. online resource. text txt rdacontent computer c rdamedia online resource cr rdacarrier text file PDF rda 1. Correlation of structure and properties of enzyme crystals in consideration of downstream processing and formulation -- 2. Multiscale Model-Based Investigation of Functional Macromolecular Agglomerates for Biotechnological Applications -- 3. Modeling-based Monitoring and Control of Protein Crystallization in Bioprocesses -- 4. Changes in structure, dispersity and phase behavior of proteins: The virus-like particles in the presence of nucleic acids. This book serves as a comprehensive summary of the priority program SPP 1934, which focused on understanding the dispersity, structure, and phase changes of proteins and bio-agglomerates in biotechnological processes. Through contributions from various research groups, the program explored how sensitive proteins and bio-agglomerates are affected by the process environment during fermentation, downstream processing, and formulation. It investigated these effects across three size scales: microscale, encompassing single proteins, clusters, crystals, and virus-like particles; mesoscale, focusing on cells and cell clusters; and macroscale, examining overall process dynamics. The main objective was to enhance biotechnological process chains by elucidating the mechanical, thermal, and chemical stresses that impact protein and bio-agglomerate structures. By gaining insights into these stressors, the program aimed to enable precise control measures to mitigate denaturation and unfavorable growth of proteins and cells. This compilation seeks to contribute to the optimization of biotechnological processes, facilitating advancements in various industries. Chemistry, Technical. 69610 Proteins . 70651 Industrial Chemistry. 69611 Protein Biochemistry. 71768 Kwade, Arno. editor. edt http://id.loc.gov/vocabulary/relators/edt 85059 Kampen, Ingo. editor. edt http://id.loc.gov/vocabulary/relators/edt 85060 SpringerLink (Online service) Springer Nature eBook Printed edition: 9783031631634 Printed edition: 9783031631658 Printed edition: 9783031631665 https://doi.org/10.1007/978-3-031-63164-1 ZDB-2-CMS ZDB-2-SXC 63738 63738