03301nam a22004575i 4500001001800000003000900018005001700027007001500044008004100059020003700100024003500137050001300172072001600185072002300201072001500224245016800239250001800407264006900425300006600494336002600560337002600586338003600612347002400648505046000672520116701132650003302299650002302332650003302355650003302388700008102421700008202502710003402584773002602618776003602644776003602680776003602716856004602752912001402798912001402812999001702826978-3-031-63164-1DE-He21320251030113107.0cr nn 008mamaa240927s2024    sz |    s    |||| 0|eng d  a97830316316419978-3-031-63164-17 a10.1007/978-3-031-63164-12doi 4aTP1-1185 7aTDC2bicssc 7aSCI0130602bisacsh 7aTDC2thema10aDispersity, Structure and Phase Changes of Proteins and Bio Agglomerates in Biotechnological Processesh[electronic resource] /cedited by Arno Kwade, Ingo Kampen.  a1st ed. 2024. 1aCham :bSpringer Nature Switzerland :bImprint: Springer,c2024.  aIX, 547 p. 276 illus., 165 illus. in color.bonline resource.  atextbtxt2rdacontent  acomputerbc2rdamedia  aonline resourcebcr2rdacarrier  atext filebPDF2rda0 a1. Correlation of structure and properties of enzyme crystals in consideration of downstream processing and formulation -- 2. Multiscale Model-Based Investigation of Functional Macromolecular Agglomerates for Biotechnological Applications -- 3. Modeling-based Monitoring and Control of Protein Crystallization in Bioprocesses -- 4. Changes in structure, dispersity and phase behavior of proteins: The virus-like particles in the presence of nucleic acids.  aThis book serves as a comprehensive summary of the priority program SPP 1934, which focused on understanding the dispersity, structure, and phase changes of proteins and bio-agglomerates in biotechnological processes. Through contributions from various research groups, the program explored how sensitive proteins and bio-agglomerates are affected by the process environment during fermentation, downstream processing, and formulation. It investigated these effects across three size scales: microscale, encompassing single proteins, clusters, crystals, and virus-like particles; mesoscale, focusing on cells and cell clusters; and macroscale, examining overall process dynamics. The main objective was to enhance biotechnological process chains by elucidating the mechanical, thermal, and chemical stresses that impact protein and bio-agglomerate structures. By gaining insights into these stressors, the program aimed to enable precise control measures to mitigate denaturation and unfavorable growth of proteins and cells. This compilation seeks to contribute to the optimization of biotechnological processes, facilitating advancements in various industries. 0aChemistry, Technical.969610 0aProteins .97065114aIndustrial Chemistry.96961124aProtein Biochemistry.9717681 aKwade, Arno.eeditor.4edt4http://id.loc.gov/vocabulary/relators/edt9850591 aKampen, Ingo.eeditor.4edt4http://id.loc.gov/vocabulary/relators/edt9850602 aSpringerLink (Online service)0 tSpringer Nature eBook08iPrinted edition:z978303163163408iPrinted edition:z978303163165808iPrinted edition:z978303163166540uhttps://doi.org/10.1007/978-3-031-63164-1  aZDB-2-CMS  aZDB-2-SXC  c63738d63738