04344nam a22005175i 4500001001800000003000900018005001700027007001500044008004100059020001800100024003500118050001000153072001600163072002300179072001500202100008000217245010400297250001800401264006900419300006700488336002600555337002600581338003600607347002400643505059100667520207501258650002303333650002703356650001703383650001403400650002403414650002403438650002303462650002303485650002403508650001703532650001403549650002403563650002503587710003403612773002603646776003603672776003603708776003603744856004603780978-3-031-68730-3DE-He21320251030113129.0cr nn 008mamaa241005s2024    sz |    s    |||| 0|eng d  a97830316873037 a10.1007/978-3-031-68730-32doi 4aQH506 7aPSD2bicssc 7aSCI0490002bisacsh 7aPSD2thema1 aCarlberg, Carsten.eauthor.4aut4http://id.loc.gov/vocabulary/relators/aut10aGene Regulation and Epigeneticsh[electronic resource] :bHow Science Works /cby Carsten Carlberg.  a1st ed. 2024. 1aCham :bSpringer Nature Switzerland :bImprint: Springer,c2024.  aXIX, 258 p. 118 illus., 117 illus. in color.bonline resource.  atextbtxt2rdacontent  acomputerbc2rdamedia  aonline resourcebcr2rdacarrier  atext filebPDF2rda0 a1. The human genome and its variations -- 2. Gene expression and chromatin -- 3. The basal transcriptional machinery -- 4. Transcription factors and signal transduction -- 5. A key transcription factor family: nuclear receptors -- 6. Genome-wide principles of gene regulation -- 7. DNA methylation -- 8. Histone modifications -- 9. Chromatin remodeling and organization -- 9. Regulatory impact of ncRNA -- 11. Epigenetics in development -- 12. Epigenetics and aging -- 13. Epigenetics and immunity -- 14. Epigenetics and disease -- 15. Cancer epigenetics -- 16. Nutritional epigenetics.  aThis book delves into the fascinating realm of eukaryotic gene regulation. The specific expression of genes shapes the phenotype of cells and tissues. The regulation of gene expression, including up- and downregulation, is a fundamental aspect of nearly all physiological processes, both in health and disease. These dynamic processes respond to various daily challenges, such as dietary changes and infections. Therefore, it is crucial for not only biologists and biochemists but also all students in biomedical disciplines to understand gene regulation concepts. This foundational knowledge will benefit them in their specialized fields. A comprehensive understanding of transcription factors and the mechanisms that alter their activity is a fundamental goal of modern life science research. Epigenetics refers to the packaging and accessibility of the genome in each of the trillions of cells in our bodies. The prefix “epi” (meaning “upon,” “above,” or “beyond”) indicates that epigenetic processes do not alter the DNA sequence of our genome, adding a layer of information beyond that encoded in our genome. Genomic DNA is wrapped around complexes of histone proteins, helping it fit into a cell nucleus with a diameter of less than 10 μm. This protein-DNA complex is known as chromatin. The content of this book is linked to the “Molecular Medicine and Genetics” course, which the author has lectured on in various forms since 2002 at the University of Eastern Finland in Kuopio. This book is an updated version of the textbooks “Mechanisms of Gene Regulation” and “Human Epigenomics.” It is divided into 16 chapters. Following two introductory chapters, four chapters explore gene regulation from the perspective of transcription factors, while another four chapters focus on chromatin and non-coding RNA. Three chapters then discuss the impact of epigenetics from a health perspective, and the final three chapters address epigenetics from the perspective of diseases. A glossary in the appendix explains the major specialist terms. 0aMolecular biology. 0aGenetic transcription. 0aEpigenetics. 0aGenomics. 0aMolecular genetics. 0aMedicinexResearch. 0aBiologyxResearch.14aMolecular Biology.24aGene Transcription.24aEpigenetics.24aGenomics.24aMolecular Genetics.24aBiomedical Research.2 aSpringerLink (Online service)0 tSpringer Nature eBook08iPrinted edition:z978303168729708iPrinted edition:z978303168731008iPrinted edition:z978303168732740uhttps://doi.org/10.1007/978-3-031-68730-3