03459nam a22004095i 4500001001800000003000900018005001700027007001500044008004100059020001800100024003500118050001400153072001600167072002300183072001500206100008000221245009400301250001800395264006900413300006500482336002600547337002600573338003600599347002400635505065600659520145101315650001602766650001402782650001602796650002302812710003402835773002602869776003602895776003602931776003602967856004603003978-3-031-61150-6DE-He21320251030113138.0cr nn 008mamaa241012s2024    sz |    s    |||| 0|eng d  a97830316115067 a10.1007/978-3-031-61150-62doi 4aRC633-647 7aMJF2bicssc 7aMED0380002bisacsh 7aMJF2thema1 aRosove, Michael H.eauthor.4aut4http://id.loc.gov/vocabulary/relators/aut10aLife’s Bloodh[electronic resource] :bThe Story of Hemoglobin /cby Michael H. Rosove.  a1st ed. 2024. 1aCham :bSpringer Nature Switzerland :bImprint: Springer,c2024.  aXIII, 130 p. 17 illus., 4 illus. in color.bonline resource.  atextbtxt2rdacontent  acomputerbc2rdamedia  aonline resourcebcr2rdacarrier  atext filebPDF2rda0 aPreface -- Chapter 1: Blood, Body, and the “Food of Life” -- Chapter 2: The Structure of Normal Human Hemoglobin -- Chapter 3: The Function of Normal Human Hemoglobin -- Chapter 4: The Oxygen Transporters -- Chapter 5: The Red Blood Cell -- Chapter 6: Malaria: Driver of Red Blood Cell and Hemoglobin Mutations -- Chapter 7: Hemoglobin and Red Blood Cells versus Malaria -- Chapter 8: Sickle Hemoglobin and Sickle Cell Disease -- Chapter 9: Hemoglobin and Red Cell Adaptation When Oxygen Is Lacking -- Chapter 10: The Porphyrias -- Chapter 11: Hemoglobin Toxins -- Chapter 12: The Quest for a Hemoglobin Substitute -- Epilogue and Acknowledgments.  aLife’s Blood: The Story of Hemoglobin encompasses the entire clinically relevant story of hemoglobin, the only molecule we have that captures oxygen from the air we breathe and delivers it to our tissues to generate the energy without which we would not exist. Dr. Rosove covers first the discoveries of oxygen, hemoglobin, and circulation of the blood, then the structure and function of human hemoglobin, together with comparisons to other oxygen transporters in the animal kingdom. He examines the red blood cell and how it protects hemoglobin, with an in-depth look at malaria and the hemoglobin and red cell mutations malaria forced us to make defending ourselves against it, particularly sickle cell disease and the thalassemias. The author also explores adaptations to the oxygen-poor environment of high altitude; lessons from freak hemoglobin mutations; hemoglobin toxins including carbon monoxide and chemicals and drugs that cause oxidant damage; and the quest for a hemoglobin substitute. Life’s Blood is a comprehensive resource for physicians, nurses, and other health professionals, at any and every stage of career development. Even seasoned hematologists, internists, and hospitalists will find something new and informative on practically every page. The book’s approachable, engaging style will also appeal to science-minded readers who will appreciate being awakened to the workings of hemoglobin, a miraculous molecule. 0aHematology. 0aMedicine.14aHematology.24aClinical Medicine.2 aSpringerLink (Online service)0 tSpringer Nature eBook08iPrinted edition:z978303161149008iPrinted edition:z978303161151308iPrinted edition:z978303161152040uhttps://doi.org/10.1007/978-3-031-61150-6