03071nam a22005175i 4500 978-981-97-4864-8 DE-He213 20251030113141.0 cr nn 008mamaa 241014s2024 si | s |||| 0|eng d 9789819748648 978-981-97-4864-8 10.1007/978-981-97-4864-8 doi R850.A1-854 QH315-320 MBGR bicssc MED106000 bisacsh MBGR thema Chemistry and Biology of O-GlcNAcylation [electronic resource] / edited by Wen Yi. 1st ed. 2024. Singapore : Springer Nature Singapore : Imprint: Springer, 2024. VII, 178 p. 44 illus., 39 illus. in color. online resource. text txt rdacontent computer c rdamedia online resource cr rdacarrier text file PDF rda Chapter 1. Chemical tools for decoding the functions of O-GlcNAcylation -- Chapter 2. Profiling O-GlcNAcylation with mass spectrometry -- Chapter 3. O-GlcNAcylation and cell metabolism -- Chapter 4. O-GlcNAcylation and transcriptional regulation and epigenetics -- Chapter 5. O-GlcNAcylation and signal transduction -- Chapter 6. O-GlcNAcylation and stem cells -- Chapter 7. O-GlcNAcylation and immune regulation -- Chapter 8. O-GlcNAcylation and neuronal development, neurodegeneration and neurological disorders. O-linked N-acetylglucosamine (O-GlcNAc) is a prevalent post-translational modification of numerous intracellular proteins. This modification has recently emerged as a key regulator of various important biological processes, including gene transcription, stress response, metabolic homeostasis, and immune regulation. Given the critical role of O-GlcNAc in normal physiology, increasing evidence has now demonstrated that deregulation of O-GlcNAc is closely associated with the development and progression of various diseases, including neurodegeneration, cardiovascular disease, and cancer. This book provides a comprehensive overview of the current progress and understanding of this modification in biology, and likely provides new research directions in the future. Medicine Research. 62598 Biology Research. 65629 Cytology. 67436 Biomedical Research. 65633 Cell Biology. 67440 Yi, Wen. editor. edt http://id.loc.gov/vocabulary/relators/edt 86001 SpringerLink (Online service) Springer Nature eBook Printed edition: 9789819748631 Printed edition: 9789819748655 Printed edition: 9789819748662 https://doi.org/10.1007/978-981-97-4864-8 ZDB-2-SBL ZDB-2-SXB 64191 64191