02851nam a22004695i 4500001001800000003000900018005001700027007001500044008004100059020003700100024003500137050001600172050001400188072001700202072002300219072001600242245008900258250001800347264007200365300006500437336002600502337002600528338003600554347002400590505051900614520077301133650003101906650003001937650002101967650003201988650002502020700007702045710003402122773002602156776003602182776003602218776003602254856004602290912001402336912001402350999001702364978-981-97-4864-8DE-He21320251030113141.0cr nn 008mamaa241014s2024    si |    s    |||| 0|eng d  a97898197486489978-981-97-4864-87 a10.1007/978-981-97-4864-82doi 4aR850.A1-854 4aQH315-320 7aMBGR2bicssc 7aMED1060002bisacsh 7aMBGR2thema10aChemistry and Biology of O-GlcNAcylationh[electronic resource] /cedited by Wen Yi.  a1st ed. 2024. 1aSingapore :bSpringer Nature Singapore :bImprint: Springer,c2024.  aVII, 178 p. 44 illus., 39 illus. in color.bonline resource.  atextbtxt2rdacontent  acomputerbc2rdamedia  aonline resourcebcr2rdacarrier  atext filebPDF2rda0 aChapter 1. Chemical tools for decoding the functions of O-GlcNAcylation -- Chapter 2. Profiling O-GlcNAcylation with mass spectrometry -- Chapter 3. O-GlcNAcylation and cell metabolism -- Chapter 4. O-GlcNAcylation and transcriptional regulation and epigenetics -- Chapter 5. O-GlcNAcylation and signal transduction -- Chapter 6. O-GlcNAcylation and stem cells -- Chapter 7. O-GlcNAcylation and immune regulation -- Chapter 8. O-GlcNAcylation and neuronal development, neurodegeneration and neurological disorders.  aO-linked N-acetylglucosamine (O-GlcNAc) is a prevalent post-translational modification of numerous intracellular proteins. This modification has recently emerged as a key regulator of various important biological processes, including gene transcription, stress response, metabolic homeostasis, and immune regulation. Given the critical role of O-GlcNAc in normal physiology, increasing evidence has now demonstrated that deregulation of O-GlcNAc is closely associated with the development and progression of various diseases, including neurodegeneration, cardiovascular disease, and cancer. This book provides a comprehensive overview of the current progress and understanding of this modification in biology, and likely provides new research directions in the future. 0aMedicinexResearch.962598 0aBiologyxResearch.965629 0aCytology.96743614aBiomedical Research.96563324aCell Biology.9674401 aYi, Wen.eeditor.4edt4http://id.loc.gov/vocabulary/relators/edt9860012 aSpringerLink (Online service)0 tSpringer Nature eBook08iPrinted edition:z978981974863108iPrinted edition:z978981974865508iPrinted edition:z978981974866240uhttps://doi.org/10.1007/978-981-97-4864-8  aZDB-2-SBL  aZDB-2-SXB  c64191d64191