04738nam a22006255i 4500 978-3-031-63118-4 DE-He213 20251030113247.0 cr nn 008mamaa 241027s2024 sz | s |||| 0|eng d 9783031631184 978-3-031-63118-4 10.1007/978-3-031-63118-4 doi QR180-189.5 MJCM bicssc MED044000 bisacsh MJCM thema Human Challenge Studies for Vaccine Development [electronic resource] / edited by Fabio Bagnoli, Giuseppe Del Giudice, Sanjay K. Phogat, Rino Rappuoli. 1st ed. 2024. Cham : Springer Nature Switzerland : Imprint: Springer, 2024. VIII, 377 p. 40 illus., 25 illus. in color. online resource. text txt rdacontent computer c rdamedia online resource cr rdacarrier text file PDF rda Current Topics in Microbiology and Immunology, 2196-9965 ; 445 A brief history of human challenge studies (1900-2021) emphasising the virology, regulatory and ethical requirements, raison d’etre, ethnography, selection of volunteers and unit design -- Regulatory aspects of human challenge studies.-Controlled Human Infection challenge studies with RSV -- Human challenge studies with coronaviruses old and new -- Experimental urethral infection with Neisseria gonorrhoeae -- Helicobacter pylori.-Controlled human infection with Bordetella pertussis Human challenge studies for cholera -- The Controlled Human Infection Model for Enterotoxigenic Escherichia coli -- Challenges in developing a controlled human tuberculosis challenge model -- Shigella Controlled Human Infection Models: Current and Future Perspectives -- The background, role and outline approach for development of a Controlled Human Infection Model for Nontyphoidal Salmonella -- Controlled Human Malaria Infection studies in Africa - past, present, and future -- Controlled infection of humans with the hookworm parasite Necator americanus to accelerate vaccine development. This volume offers insights into human challenge studies, where adult volunteers are deliberately infected with a pathogen of interest. These studies can broaden our knowledge on infections that have a rather low natural infection rate, but still bear a great threat to global health. The authors also present instances, where no suitable animal model is available to help understand human immune responses to a specific pathogen. The recent SARS-CoV-2 pandemic is another example, where studies that are directly conducted in humans, could save valuable time. Human challenge studies can provide immunogenicity and early efficacy data for vaccine development. However, similar models could be used for studying a wide variety of medical treatments such as monoclonal antibodies, antibiotics, antivirals and bacteriophages. The chapters in this volume cover several pathogens, including viruses, bacteria and parasites, scientific and technical aspects as well as descriptions of regulatory, ethical and manufacturing requirements. The book serves as a valuable resource for scientists and clinicians working on human pathogens. Immunology. 69214 Medical microbiology. 63858 Medicine Research. 62598 Biology Research. 65629 Diseases Causes and theories of causation. 78871 Immunology. 69214 Medical Microbiology. 63858 Translational Research. 70704 Pathogenesis. 78872 Bagnoli, Fabio. editor. edt http://id.loc.gov/vocabulary/relators/edt 86682 Del Giudice, Giuseppe. editor. edt http://id.loc.gov/vocabulary/relators/edt 86683 Phogat, Sanjay K. editor. edt http://id.loc.gov/vocabulary/relators/edt 86684 Rappuoli, Rino. editor. edt http://id.loc.gov/vocabulary/relators/edt 86685 SpringerLink (Online service) Springer Nature eBook Printed edition: 9783031631177 Printed edition: 9783031631191 Printed edition: 9783031631207 Current Topics in Microbiology and Immunology, 2196-9965 ; 445 86686 https://doi.org/10.1007/978-3-031-63118-4 ZDB-2-SBL ZDB-2-SXB 64531 64531