03870nam a22005055i 4500001001800000003000900018005001700027007001500044008004100059020001800100024003500118050001600153072001700169072001700186072002300203072001600226072001600242245012200258250001800380264006900398300006300467336002600530337002600556338003600582347002400618490007000642505053600712520155801248650002902806650001702835650002302852650002602875650003402901650001702935650002002952650002602972700008202998710003403080773002603114776003603140776003603176776003603212830007003248856004603318978-3-031-66686-5DE-He21320251030113326.0cr nn 008mamaa241126s2024    sz |    s    |||| 0|eng d  a97830316668657 a10.1007/978-3-031-66686-52doi 4aRC268.4-.44 7aPSAK2bicssc 7aMJCL2bicssc 7aSCI0290002bisacsh 7aPSAK2thema 7aMJCL2thema10aEpigenetic Mechanisms in Breast Cancer Therapy and Resistanceh[electronic resource] /cedited by Sanchita Bhatnagar.  a1st ed. 2024. 1aCham :bSpringer Nature Switzerland :bImprint: Springer,c2024.  aV, 106 p. 24 illus., 23 illus. in color.bonline resource.  atextbtxt2rdacontent  acomputerbc2rdamedia  aonline resourcebcr2rdacarrier  atext filebPDF2rda1 aAdvances in Experimental Medicine and Biology,x2214-8019 ;v14650 aChapter 1 - MDIG in breast cancer progression and metastasis -- Chapter 2 - Tumor Microenvironment and Epigenetic Implications in Breast Cancer Progression -- Chapter 3 - The Epigenetic Landscape of Breast Cancer, Metabolism, and Obesity -- Chapter 4 - Epigenetic Modulations by Microbiome in Breast Cancer -- Chapter 5 - Facilitates chromatin transcription in breast and other cancers -- Chapter 6 - Advances in epigenetic therapeutics for breast cancer -- Chapter 7 - Detection methods for epigenetic mechanisms in breast cancer.  aEpigenetic mechanisms are essential for normal mammalian development and maintenance of gene expression patterns. Disruption of epigenetic processes can lead to altered transcriptional regulation, gene levels, and malignant cellular transformation. Global alterations of the epigenetic landscape are a hallmark of tumorigenesis and metastasis. Conventionally, cancer was thought to be a genetic disease, but recent advancement in the field identified an abundance of epigenetic abnormalities along with genetic alterations. The extensive reprogramming of epigenetic machinery in cancer includes DNA methylation, histone modifications, nucleosome positioning and non-coding RNAs, specifically microRNA expression. Additionally, the reversible nature of epigenetic aberrations has led to the emergence of the promising field of epigenetic therapy, and recent FDA approval of epigenetic drugs for cancer treatment. This book focuses on the epigenetic mechanisms in breast cancertherapy and resistance. It is organized into three sections, including epigenetic mechanisms in breast cancer, targeting epigenetic mechanisms for new therapies, and new and emerging methodologies to study epigenetic alterations in breast cancer. Chapters highlight various epigenetic regulations that prevent breast cancer growth and progression, as well as epigenetic alterations that contribute to breast cancer progression. This text is a useful methodology book for researchers and students interested in epigenetics in breast cancer and the fundamentals of cancer biology. 0aCancerxGenetic aspects. 0aEpigenetics. 0aCancerxTreatment. 0aMedical microbiology.14aCancer Genetics and Genomics.24aEpigenetics.24aCancer Therapy.24aMedical Microbiology.1 aBhatnagar, Sanchita.eeditor.4edt4http://id.loc.gov/vocabulary/relators/edt2 aSpringerLink (Online service)0 tSpringer Nature eBook08iPrinted edition:z978303166685808iPrinted edition:z978303166687208iPrinted edition:z9783031666889 0aAdvances in Experimental Medicine and Biology,x2214-8019 ;v146540uhttps://doi.org/10.1007/978-3-031-66686-5