04287nam a22006015i 4500 978-3-031-66686-5 DE-He213 20251030113326.0 cr nn 008mamaa 241126s2024 sz | s |||| 0|eng d 9783031666865 978-3-031-66686-5 10.1007/978-3-031-66686-5 doi RC268.4-.44 PSAK bicssc MJCL bicssc SCI029000 bisacsh PSAK thema MJCL thema Epigenetic Mechanisms in Breast Cancer Therapy and Resistance [electronic resource] / edited by Sanchita Bhatnagar. 1st ed. 2024. Cham : Springer Nature Switzerland : Imprint: Springer, 2024. V, 106 p. 24 illus., 23 illus. in color. online resource. text txt rdacontent computer c rdamedia online resource cr rdacarrier text file PDF rda Advances in Experimental Medicine and Biology, 2214-8019 ; 1465 Chapter 1 - MDIG in breast cancer progression and metastasis -- Chapter 2 - Tumor Microenvironment and Epigenetic Implications in Breast Cancer Progression -- Chapter 3 - The Epigenetic Landscape of Breast Cancer, Metabolism, and Obesity -- Chapter 4 - Epigenetic Modulations by Microbiome in Breast Cancer -- Chapter 5 - Facilitates chromatin transcription in breast and other cancers -- Chapter 6 - Advances in epigenetic therapeutics for breast cancer -- Chapter 7 - Detection methods for epigenetic mechanisms in breast cancer. Epigenetic mechanisms are essential for normal mammalian development and maintenance of gene expression patterns. Disruption of epigenetic processes can lead to altered transcriptional regulation, gene levels, and malignant cellular transformation. Global alterations of the epigenetic landscape are a hallmark of tumorigenesis and metastasis. Conventionally, cancer was thought to be a genetic disease, but recent advancement in the field identified an abundance of epigenetic abnormalities along with genetic alterations. The extensive reprogramming of epigenetic machinery in cancer includes DNA methylation, histone modifications, nucleosome positioning and non-coding RNAs, specifically microRNA expression. Additionally, the reversible nature of epigenetic aberrations has led to the emergence of the promising field of epigenetic therapy, and recent FDA approval of epigenetic drugs for cancer treatment. This book focuses on the epigenetic mechanisms in breast cancertherapy and resistance. It is organized into three sections, including epigenetic mechanisms in breast cancer, targeting epigenetic mechanisms for new therapies, and new and emerging methodologies to study epigenetic alterations in breast cancer. Chapters highlight various epigenetic regulations that prevent breast cancer growth and progression, as well as epigenetic alterations that contribute to breast cancer progression. This text is a useful methodology book for researchers and students interested in epigenetics in breast cancer and the fundamentals of cancer biology. Cancer Genetic aspects. 73501 Epigenetics. 77287 Cancer Treatment. 63722 Medical microbiology. 63858 Cancer Genetics and Genomics. 73502 Epigenetics. 77287 Cancer Therapy. 73414 Medical Microbiology. 63858 Bhatnagar, Sanchita. editor. edt http://id.loc.gov/vocabulary/relators/edt 87995 SpringerLink (Online service) Springer Nature eBook Printed edition: 9783031666858 Printed edition: 9783031666872 Printed edition: 9783031666889 Advances in Experimental Medicine and Biology, 2214-8019 ; 1465 67831 https://doi.org/10.1007/978-3-031-66686-5 ZDB-2-SBL ZDB-2-SXB 65184 65184