03928nam a22005175i 4500001001800000003000900018005001700027007001500044008004100059020001800100024003500118050001400153050001400167072001700181072002300198072001600221245009200237250001800329264006900347300006500416336002600481337002600507338003600533347002400569490006600593505065100659520153301310650001202843650001602855650002302871650003502894650001902929650002302948650002002971650002002991650002303011650001903034700007703053710003403130773002603164776003603190776003603226776003603262830006603298856004603364978-3-031-74842-4DE-He21320251030114914.0cr nn 008mamaa250101s2024    sz |    s    |||| 0|eng d  a97830317484247 a10.1007/978-3-031-74842-42doi 4aRC261-271 4aQH588.S83 7aMJCL2bicssc 7aMED0620002bisacsh 7aMJCL2thema10aCancer Stem Cells and Cancer Therapyh[electronic resource] /cedited by Rasime Kalkan.  a1st ed. 2024. 1aCham :bSpringer Nature Switzerland :bImprint: Springer,c2024.  aXXI, 376 p. 37 illus., 36 illus. in color.bonline resource.  atextbtxt2rdacontent  acomputerbc2rdamedia  aonline resourcebcr2rdacarrier  atext filebPDF2rda1 aStem Cell Biology and Regenerative Medicine,x2196-8993 ;v760 aCharacteristics of Stem Cells and Cancer Stem Cells -- Stem Cell Niche -- Hypoxia, Stem Cells and Cancer Stem Cells -- Altered Wnt Pathway and Cancer Stem Cells -- Altered PI3K/AKT/MTOR Pathway and Cancer Stem Cells -- Altered NOTCH Pathway and Cancer Stem Cells -- Cancer Stem Cells And Immunity -- Cancer Stem Cells and Tumor MicrobiomeCancer Stem Cells in the Hematopoietic SystemUnderstanding The Role Of Cancer Stem Cells In Brain Tumor Pathogenesis -- Cancer Stem Cells in Lung Cancer, A Novel FrontierCancer Stem Cells in Gastrointestinal CancersCancer Stem Cells in Breast Cancer -- The Role Of CAR-T Cells in Targeting Cancer Stem Cells.  aThis book explores the importance of cancer stem cells and their usage. Cancer is a serious health issue that affects people all over the world. Numerous studies back up the theory that stem cells play a role in cancer development. The population of cancer stem cells (CSCs) exhibits tumorigenic potential and possesses stem cell-specific markers and characteristics, such as self-renewal/proliferation and differentiation. Carcinogenesis may be significantly influenced by CSCs. Currently, treatment techniques concentrate on eliminating the CSC subpopulation using various methods, such as bypassing CSC resistance mechanisms or focussing on important biochemical pathways that govern these cells. New approaches are still required even though the negative effects of current treatment approaches are minimal. The information that has been gathered on the stem cell theory of carcinogenesis, the impact of dysregulated stem cell self-renewal on cancer transformation, and the functions of CSCs in cancer treatment are presented in this book. We also discuss how a deeper comprehension of the biology, behaviour, and environment of CSCs can advance the use of these cells in cancer therapy and lead to the development of more potent cancer treatment plans. Given its scope, Cancer Stem Cells and Cancer Therapy is an indispensable resource not only for researchers working in the field of human biology and cancer research but also for advanced students seeking an introduction to cancer stem cells and their therapeutic usage. 0aCancer. 0aStem cells. 0aCancerxTreatment. 0aTumorsxImmunological aspects. 0aImmunotherapy.14aCancer Stem Cells.24aCancer Therapy.24aCancer Biology.24aTumour Immunology.24aImmunotherapy.1 aKalkan, Rasime.eeditor.4edt4http://id.loc.gov/vocabulary/relators/edt2 aSpringerLink (Online service)0 tSpringer Nature eBook08iPrinted edition:z978303174841708iPrinted edition:z978303174843108iPrinted edition:z9783031748448 0aStem Cell Biology and Regenerative Medicine,x2196-8993 ;v7640uhttps://doi.org/10.1007/978-3-031-74842-4