04362nam a22006135i 4500 978-3-031-74842-4 DE-He213 20251030114914.0 cr nn 008mamaa 250101s2024 sz | s |||| 0|eng d 9783031748424 978-3-031-74842-4 10.1007/978-3-031-74842-4 doi RC261-271 QH588.S83 MJCL bicssc MED062000 bisacsh MJCL thema Cancer Stem Cells and Cancer Therapy [electronic resource] / edited by Rasime Kalkan. 1st ed. 2024. Cham : Springer Nature Switzerland : Imprint: Springer, 2024. XXI, 376 p. 37 illus., 36 illus. in color. online resource. text txt rdacontent computer c rdamedia online resource cr rdacarrier text file PDF rda Stem Cell Biology and Regenerative Medicine, 2196-8993 ; 76 Characteristics of Stem Cells and Cancer Stem Cells -- Stem Cell Niche -- Hypoxia, Stem Cells and Cancer Stem Cells -- Altered Wnt Pathway and Cancer Stem Cells -- Altered PI3K/AKT/MTOR Pathway and Cancer Stem Cells -- Altered NOTCH Pathway and Cancer Stem Cells -- Cancer Stem Cells And Immunity -- Cancer Stem Cells and Tumor MicrobiomeCancer Stem Cells in the Hematopoietic SystemUnderstanding The Role Of Cancer Stem Cells In Brain Tumor Pathogenesis -- Cancer Stem Cells in Lung Cancer, A Novel FrontierCancer Stem Cells in Gastrointestinal CancersCancer Stem Cells in Breast Cancer -- The Role Of CAR-T Cells in Targeting Cancer Stem Cells. This book explores the importance of cancer stem cells and their usage. Cancer is a serious health issue that affects people all over the world. Numerous studies back up the theory that stem cells play a role in cancer development. The population of cancer stem cells (CSCs) exhibits tumorigenic potential and possesses stem cell-specific markers and characteristics, such as self-renewal/proliferation and differentiation. Carcinogenesis may be significantly influenced by CSCs. Currently, treatment techniques concentrate on eliminating the CSC subpopulation using various methods, such as bypassing CSC resistance mechanisms or focussing on important biochemical pathways that govern these cells. New approaches are still required even though the negative effects of current treatment approaches are minimal. The information that has been gathered on the stem cell theory of carcinogenesis, the impact of dysregulated stem cell self-renewal on cancer transformation, and the functions of CSCs in cancer treatment are presented in this book. We also discuss how a deeper comprehension of the biology, behaviour, and environment of CSCs can advance the use of these cells in cancer therapy and lead to the development of more potent cancer treatment plans. Given its scope, Cancer Stem Cells and Cancer Therapy is an indispensable resource not only for researchers working in the field of human biology and cancer research but also for advanced students seeking an introduction to cancer stem cells and their therapeutic usage. Cancer. 4311 Stem cells. 67435 Cancer Treatment. 63722 Tumors Immunological aspects. 73413 Immunotherapy. 69215 Cancer Stem Cells. 78674 Cancer Therapy. 73414 Cancer Biology. 67829 Tumour Immunology. 73415 Immunotherapy. 69215 Kalkan, Rasime. editor. edt http://id.loc.gov/vocabulary/relators/edt 90007 SpringerLink (Online service) Springer Nature eBook Printed edition: 9783031748417 Printed edition: 9783031748431 Printed edition: 9783031748448 Stem Cell Biology and Regenerative Medicine, 2196-8993 ; 76 71552 https://doi.org/10.1007/978-3-031-74842-4 ZDB-2-SBL ZDB-2-SXB 66261 66261