06072nam a22005535i 4500001001800000003000900018005001700027007001500044008004100059020003700100024003500137050001400172072001600186072001600202072002300218072001500241245018400256250001800440264006900458300006600527336002600593337002600619338003600645347002400681505239900705520164303104650002504747650002604772650003704798650004304835650003304878650002804911650002504939650002604964650002604990650003505016650003305051650004105084700008805125700008205213710003405295773002605329776003605355776003605391856004605427912001405473912001405487999001705501978-3-031-75457-9DE-He21320251030114930.0cr nn 008mamaa250124s2024    sz |    s    |||| 0|eng d  a97830317545799978-3-031-75457-97 a10.1007/978-3-031-75457-92doi 4aRS400-431 7aPNN2bicssc 7aPSB2bicssc 7aSCI0130202bisacsh 7aPNB2thema10aGlobal Trends in Health, Technology and Managementh[electronic resource] :bProceedings of the 1st International Symposium GTHTM-2024 /cedited by Anil Kumar Saxena, Sisir Nandi.  a1st ed. 2024. 1aCham :bSpringer Nature Switzerland :bImprint: Springer,c2024.  aXIX, 387 p. 251 illus., 86 illus. in color.bonline resource.  atextbtxt2rdacontent  acomputerbc2rdamedia  aonline resourcebcr2rdacarrier  atext filebPDF2rda0 aChapter 1 Quantitative Structure Interaction Activity Relationship (QSIAR) a Novel Approach to Drug Design: A Case Study of Anti-tubercular Agents -- Chapter 2 ONCORx: A digital App for cancer treatment planning -- Chapter 3 Amprenavir-Ritonavir combination is more effective in Leishmania donovani compared to Leishmania major -- Chapter 4 A Hands-on Perspective on Physico-Chemical Versus AI/ML Methods along the Genome to Drug Pathway -- Chapter 5 Elucidation of the Binding Modes of Known Potent Inhibitors at Mycobacterial FOF1-ATP Synthase Subunits c and ε -- Chapter 6 Docking-based experimental approach examining the effectiveness of nano-formulations as diabetes therapeutics -- Chapter 7 Nano-phytocompound combats food-additive induced genotoxicity and mitochondrial dysfunction in diabetic model: an in silico predicted experimental study -- Chapter 8 Optimizing solubility through co-crystal technology: A rigorous investigation into tablets loaded with azelnidipine co-crystals -- Chapter 9 Natural product and their derivatives: Promising caspase-3 activators as anticancer agents -- Chapter 10 Modeling of the Cyclic Guanidines As 5-HT5A Receptor Ligands Using Chemometric Tools -- Chapter 11 Computer-Aided Drug Design of Potential Anti-tubercular Drug Targeting the Mycobacterial F-type ATP Synthase Enzyme -- Chapter 12 Natural drugs to combat Dengue Fever -- Chapter 13 Development and Assessment of Nanostructured Lipid Carriers loaded with Calotropis gigantea Extract for the Enhancement of Therapeutic Effect -- Chapter 14 Identification of Novel Potent KRASG12D Inhibitors Through Target-Based Virtual Screening -- Chapter 15 Oncolytic Viral Therapy: A Promising Approach in Cancer Treatment -- Chapter 16 QSAR of repurposed AntiCOVID-19 chemotherapeutics utilizing theoretical structural descriptors -- Chapter 17 Nanosuspension Formulation – ActivityRelationship of anticancercompounds to enhance therapeutic efficacy of gastric cancer -- Chapter 18 Effects of commonly used pesticides on gut microbiota -- Chapter 19 Pharmacophore Modeling of Tricyclic Antipsychotics -- Chapter 20 Novel synthesis of 3,5-disubstituted-5H-thiazolo[3, 2 -α]pyrimidine -- Chapter 21 Insights into the Structure and Function of ClpP from the Mycobacterium genus -- Chapter 22 Novel Synthesis of 1-arylnaphtho[1,2-d]isoxazole through oxidation of 1-amidoalkyl-2-naphthols using MnO2.  aThis book presents the proceedings of the 1st International Symposium on Global Trends in Health, Technology and Management (GTHTM-2024), held on March 15-17, 2024, in Dehradun, India. It reports on recent advances in the interdisciplinary fields of health, technology, and management covering a broad spectrum of topics like drug discovery and development including diseases like cancer, tropical and lifestyle diseases, agroecology, artificial intelligence, and machine learning. The symposium is jointly organised by the Global Health Techno Management Forum and the Global Institute of Pharmaceutical Education and Research, Kashipur, India, together with the Veer Madho Singh Bhandari Uttarakhand Technical University, Dehradun, India. It builds on the success of previous conferences such as the International Symposium on Drug Design and Development Research (DDDR-2021), International Symposium on Current Trends in Pharmaceutical and Medical Sciences (CTPMS-2020), International seminar on Global Trends in Health and Environment (2016), International Seminar on Pharmaceutical Education and Research (ISPER-2010), and the 9th International Symposium on Computational Methods in Toxicology and Pharmacology Integrating Internet Resources (CMTPI-2017). Offering a timely snapshot of cutting-edge, multidisciplinary research and developments in drug design and health sciences, these proceedings facilitate the transfer of these findings to industry and offer a unique perspective on One Health sustainability. As such, the book will appeal not only to students and researchers but also to professionals interested in these fields. 0aMedicinal chemistry. 0aPublic health.961312 0aPharmaceutical chemistry.967843 0aHealth services administration.961649 0aEnvironmental health.962224 0aSocial medicine.96245614aMedicinal Chemistry.24aPublic Health.96131224aPharmaceutics.96784624aHealth Care Management.96700624aEnvironmental Health.96222424aHealth, Medicine and Society.9698531 aSaxena, Anil Kumar.eeditor.4edt4http://id.loc.gov/vocabulary/relators/edt9904151 aNandi, Sisir.eeditor.4edt4http://id.loc.gov/vocabulary/relators/edt9904162 aSpringerLink (Online service)0 tSpringer Nature eBook08iPrinted edition:z978303175456208iPrinted edition:z978303175458640uhttps://doi.org/10.1007/978-3-031-75457-9  aZDB-2-SME  aZDB-2-SXM  c66500d66500