03258nam a22004455i 4500001001800000003000900018005001700027007001500044008004100059020001800100024003500118050001600153072001600169072002300185072001500208100008700223245008900310250001800399264006900417300006600486336002600552337002600578338003600604347002400640505043700664520134101101650001702442650003002459650002902489650002302518650001502541650002802556650002702584650002302611710003402634773002602668776003602694776003602730856004602766978-3-031-77171-2DE-He21320251030114932.0cr nn 008mamaa250126s2024    sz |    s    |||| 0|eng d  a97830317717127 a10.1007/978-3-031-77171-22doi 4aRC346-429.2 7aMJN2bicssc 7aMED0560002bisacsh 7aMKJ2thema1 aTriadafilopoulos, George.eauthor.4aut4http://id.loc.gov/vocabulary/relators/aut14aThe Gut in Parkinson's Diseaseh[electronic resource] /cby George Triadafilopoulos.  a1st ed. 2024. 1aCham :bSpringer Nature Switzerland :bImprint: Springer,c2024.  aXIII, 176 p. 81 illus., 71 illus. in color.bonline resource.  atextbtxt2rdacontent  acomputerbc2rdamedia  aonline resourcebcr2rdacarrier  atext filebPDF2rda0 aIntroduction -- Parkinson’s disease (PD) - Generalities -- Parkinson’s disease (PD) and the gut - Gut PD -- Understanding the essentials of the normal gut movement and sensation -- What to watch for in gut PD: Mouth -- Pharynx and esophagus -- Small intestine -- Small intestinal bacterial overgrowth (SIBO) Colon -- Malnutrition and weight loss in PD -- Diagnostic and Assessment tools in PD -- GI symptom questionnaires in PD.  aAt present, there is minimal and misleading knowledge of gastrointestinal dysfunction in Parkinson's disease among primary neurologists and gastroenterologists. This book reviews our current understanding of the GI involvement in PD, as many experiments suggest that the gut might be the site where the disease starts. Also discussed is how the gut dysfunction causes symptoms from the top (mouth) to the bottom (anal canal), and because of their frequency and severity, they contribute to disease progression and disability. In addition, the book covers the negative effects of small intestinal bacterial overgrowth (SIBO) and of a frequently silent stomach infection by Helicobacter pylori infection on the absorption of antiparkinsonian drugs, in turn causing motor fluctuations and inadequate treatment response. The Gut in Parkinson's Disease serves as a bridge between patients, their movement disorders specialists, and other health care providers who currently provide compartmentalized and at times conflicting care for such needy patients. The book distills the clinical and research experience of the author, who -as a Clinical Professor of Medicine (Gastroenterology) at Stanford University School of Medicine over the past 20 years- managed hundreds of patients with Parkinson’s Disease suffering from gut manifestations. 0aNeurology . 0aNervous systemxDiseases. 0aPrimary care (Medicine). 0aPatient education.14aNeurology.24aNeurological Disorders.24aPrimary Care Medicine.24aPatient Education.2 aSpringerLink (Online service)0 tSpringer Nature eBook08iPrinted edition:z978303177170508iPrinted edition:z978303177172940uhttps://doi.org/10.1007/978-3-031-77171-2