04240nam a22006615i 4500 978-3-031-81025-1 DE-He213 20251030114949.0 cr nn 008mamaa 250306s2024 sz | s |||| 0|eng d 9783031810251 978-3-031-81025-1 10.1007/978-3-031-81025-1 doi RS400-431 PNN bicssc PSB bicssc SCI013020 bisacsh PNB thema Biotherapeutics [electronic resource] : From small to large molecules and cells / edited by Victoria Calzada, Hugo Cerecetto, Juan Pablo Tosar. 1st ed. 2024. Cham : Springer Nature Switzerland : Imprint: Springer, 2024. VIII, 355 p. online resource. text txt rdacontent computer c rdamedia online resource cr rdacarrier text file PDF rda Topics in Medicinal Chemistry, 1862-247X ; 42 Section 1 Basic concepts and definitions -- Medicinal chemistry and biotherapeutics Overview and definitions -- Biotherapeutics General introduction. This book reviews biotherapeutics from a medicinal chemistry perspective. It covers proteins, nucleic acids, low molecular weight hormones, small peptides, extracellular vesicles, gene therapy, cell-based products, and tissue-engineered products. Expert contributors provide insights into the mechanisms of action and translational processes of biotherapeutics. Particular attention is given to the latest developments in therapeutic proteins and nucleic acids. Biotherapeutic formulation developments like encapsulation, structural modifications and nanovehiculization are also presented in this book. Divided into 15 chapters, the book begins with basic concepts and definitions of biotherapeutics from a medicinal chemistry standpoint. The following chapters focus on therapeutic proteins, monoclonal antibodies, protein production, and structural modifications. Other chapters cover topics such as antisense oligonucleotides, aptamers, mRNA, gene therapy, as well as other biotherapeutics like low molecular weight hormones and small peptides. The book concludes with an overview of biotherapeutic formulations and an authoritative discussion on regulatory aspects. Throughout the book, readers will learn how biotherapeutics, whether obtained through bioprocesses or not, impact bioresponses and can be utilized for therapeutic purposes. Given its breadth, the book appeals to researchers in medicinal chemistry and biotherapeutics, scholars of medicinal chemistry, students at all levels of biochemical studies, practitioners in the medical field, and anyone interested in biotherapeutics. Medicinal chemistry. Therapeutics. 70087 Proteins. 70651 Clinical biochemistry. 67825 Medicine Research. 62598 Biology Research. 65629 Biomedical engineering. Medicinal Chemistry. Therapeutics. 70087 Proteins. 70651 Medical Biochemistry. 67828 Biomedical Research. 65633 Biomedical Engineering and Bioengineering. Calzada, Victoria. editor. edt http://id.loc.gov/vocabulary/relators/edt 91005 Cerecetto, Hugo. editor. edt http://id.loc.gov/vocabulary/relators/edt 91006 Tosar, Juan Pablo. editor. edt http://id.loc.gov/vocabulary/relators/edt 91007 SpringerLink (Online service) Springer Nature eBook Printed edition: 9783031810244 Printed edition: 9783031810268 Printed edition: 9783031810275 Topics in Medicinal Chemistry, 1862-247X ; 42 91008 https://doi.org/10.1007/978-3-031-81025-1 ZDB-2-CMS ZDB-2-SXC 66822 66822