04172nam a22003974u 4500 10.1002/9781119824572 Wiley 20251030120303.0 cr nn 008mam|a 240205t2024||||xxu fs| |0|| 0|eng|| 9781119824572 electronic 10.1002/9781119824572 doi eng Precision Cancer Therapies vol 2 ‐ Immunologic Approaches for the Treatment of Lymphoid Malignancies ‐ From Concept to Practice [electronic resource] Edited by Owen A. O'Connor, Stephen M. Ansell, John G. Gribben. 1 Wiley 2024 Wiley 2024 496pp.; text txt rdacontent computer c rdamedia online resource cr rdacarrier text file rdaft PDF Presents timely and authoritative information on the development of precision cancer therapies as applied to hematologic malignancies The Precision Cancer Therapies series focuses on how to understand and translate fundamental basic science into information that can be directly applied to patients to advance care. Each volume of the series integrates the relevant biological concepts and principles necessary for translating this science to practitioners of this science. Precision Cancer Therapies, Volume Two, focuses on sophisticated immunotherapies targeting cancers affecting the blood, bone marrow, and lymph nodes. Edited and authored by the foremost authorities in the field, this comprehensive reference text covers targeting of cell surface receptors, antibody-drug conjugates (ADC), targeting immune checkpoint, targeting macrophages, EBV-directed immunotherapies, tumor-associated antigens (TAA), and chimeric antigen receptor T-cells (CAR-T). Divided into nine sections, Volume Two includes an overview of the history of immunotherapy development in cancer, as well as a concluding section addressing the mechanistic basis and role of immunomodulatory drugs, analytical tools to quantitate immune-mediated effects, and other topics in immunotherapy. Chapters on specific therapeutics or therapeutic classes include a basic explanation of the underlying pathway and target, the pharmacology of the drug/class, relevant preclinical and clinical data, and discussion of clinical management and potential predictive biomarkers of response. This book also: Delivers a definitive, state-of-the-art review of the relevant biology and its importance in the broader context of cancer biology Focuses on agents that mediate cell killing in lymphoma through a variety of immunologic mechanisms Covers FDA-approved drugs and their indications, as well as drugs currently in development Provides information on monotherapy and combination therapy, summary tables of trials, and discussion of toxicity and efficacy Includes boxed sections highlighting major unique points about the information in the chapter Precision Cancer Therapies, Volume Two: Immunologic Approaches for the Treatment of Lymphoid Malignancies, From Concept to Practice is an indispensable resource for medical, scientific, and allied medical professionals, advanced students, and interested general readers with background knowledge in the subject. Medical Oncology 64358 Hematology 76927 immunotherapy hematologic malignancies; lymphoid malignancies pharmacology; lymphoid malignancies ADC; immune checkpoint lymphoma; EBV immunotherapies; T-CELLS lymphoma; therapeutic targeting; CAR-T Cells lymphomas; EBV immunotherapies O'Connor, Owen A. edt 91091 Ansell, Stephen M. edt 91092 Gribben, John G. edt 91093 Printed edition: 9781119824541 https://doi.org/10.1002/9781119824572 Wiley Online Library https://onlinelibrary.wiley.com/action/showBook?doi=10.1002%2F9781119824572 Wiley Online Library Cover Image https://onlinelibrary.wiley.com/cms/asset/0bb0f673-ed08-42a4-9253-c0e908091a42/9781119824572.cover.gif Wiley Online Library 66861 66861