02342nam a22003734u 450000100220000000300060002200500170002800700150004500800410006002000300010102400310013104100080016210000280017024501100019825000060030826000160031426400160033030000120034633600260035833700260038433800360041034700210044634700080046752008460047565000440132165000290136565000270139465301770142170000260159877600360162485600640166085601020172485601420182610.1002/9781394276639Wiley20251030120304.0cr nn 008mam|a240221t2024||||xxu    fs|   |0|| 0|eng||  a9781394276639qelectronic7 a10.1002/97813942766392doi  aeng1 aMasquida, Benoît4aut10aLooking at RibozymesbBiology of Catalytic RNAh[electronic resource]cBenoît Masquida, Fabrice Leclerc  a1  bWileyc2024 1bWileyc2024  a192pp.;  atextbtxt2rdacontent  acomputerbc2rdamedia  aonline resourcebcr2rdacarrier  atext file2rdaft  bPDF  aBehind the neologism "ribozymes" lies a family of fascinating molecules, ribo-enzymes, which have been relatively little studied. These catalytically active RNAs are found in all strata of life, from viruses to the human genome. At the end of the 1970s, the discovery of a catalytic RNA nestled in an intron, followed by another involved in the maturation of transfer RNAs, led to the discovery of new ribozymes and the transition from a strictly "proteocentric" vision, inherited from the dogma of molecular biology, to a more "nucleocentric" one. Since then, a variety of ribozymes have been identified in genomes, where their functions often remain mysterious. Looking at Ribozymes traces the discovery of these molecules and presents a picture of their functional diversity, catalytic mechanisms and distribution within the tree of life. 4aBiomolecules (DNA, RNA, Peptides, etc.) 4aCell & Molecular Biology 4aMolecular Microbiology00aribozymes; ribo-enzymes; catalytic RNA; intron; transfer RNAs; molecular biology; proteocentric; nucleocentric; genomes; functional diversity; catalytic mechanisms1 aLeclerc, Fabrice4aut08iPrinted edition:z978178630977840uhttps://doi.org/10.1002/9781394276639aWiley Online Library40uhttps://onlinelibrary.wiley.com/action/showBook?doi=10.1002%2F9781394276639aWiley Online Library423Cover Imageuhttps://onlinelibrary.wiley.com/cms/asset/ea768d81-a4f2-4ea1-a6e2-4a4ece614eda/9781394276639.cover.gifaWiley Online Library