02450nam a22003974u 4500 10.1002/9781394276639 Wiley 20251030120304.0 cr nn 008mam|a 240221t2024||||xxu fs| |0|| 0|eng|| 9781394276639 electronic 10.1002/9781394276639 doi eng Masquida, Benoît aut 91322 Looking at Ribozymes Biology of Catalytic RNA [electronic resource] Benoît Masquida, Fabrice Leclerc 1 Wiley 2024 Wiley 2024 192pp.; text txt rdacontent computer c rdamedia online resource cr rdacarrier text file rdaft PDF Behind the neologism "ribozymes" lies a family of fascinating molecules, ribo-enzymes, which have been relatively little studied. These catalytically active RNAs are found in all strata of life, from viruses to the human genome. At the end of the 1970s, the discovery of a catalytic RNA nestled in an intron, followed by another involved in the maturation of transfer RNAs, led to the discovery of new ribozymes and the transition from a strictly "proteocentric" vision, inherited from the dogma of molecular biology, to a more "nucleocentric" one. Since then, a variety of ribozymes have been identified in genomes, where their functions often remain mysterious. Looking at Ribozymes traces the discovery of these molecules and presents a picture of their functional diversity, catalytic mechanisms and distribution within the tree of life. Biomolecules (DNA, RNA, Peptides, etc.) 91323 Cell & Molecular Biology 91076 Molecular Microbiology 91324 ribozymes; ribo-enzymes; catalytic RNA; intron; transfer RNAs; molecular biology; proteocentric; nucleocentric; genomes; functional diversity; catalytic mechanisms Leclerc, Fabrice aut 91325 Printed edition: 9781786309778 https://doi.org/10.1002/9781394276639 Wiley Online Library https://onlinelibrary.wiley.com/action/showBook?doi=10.1002%2F9781394276639 Wiley Online Library Cover Image https://onlinelibrary.wiley.com/cms/asset/ea768d81-a4f2-4ea1-a6e2-4a4ece614eda/9781394276639.cover.gif Wiley Online Library 66917 66917