02464nam a22003734u 450000100220000000300060002200500170002800700150004500800410006002000300010102400310013104100080016210000300017024500810020025000060028126000160028726400160030330000120031933600260033133700260035733800360038334700210041934700080044052010310044865000360147965000320151565000240154765301510157170000240172277600360174685600640178285601020184685601420194810.1002/9781394299096Wiley20251030120307.0cr nn 008mam|a240702t2024||||xxu    fs|   |0|| 0|eng||  a9781394299096qelectronic7 a10.1002/97813942990962doi  aeng1 aKirkiacharian, Serge4aut10aEnzymes and Drugsh[electronic resource]cSerge Kirkiacharian, Julien Dumond  a1  bWileyc2024 1bWileyc2024  a224pp.;  atextbtxt2rdacontent  acomputerbc2rdamedia  aonline resourcebcr2rdacarrier  atext file2rdaft  bPDF  aEnzyme dysfunction, an essential catalyst for the smooth running of biochemical reactions and the maintenance of vital processes, is at the root of many pathologies that have paved the way for the development of numerous drugs. Aimed at pharmacists, biologists, biochemists, doctors, veterinarians, medicinal chemists and students from a wide range of disciplines, Enzymes and Drugs brings together, for the first time, extensive documentation highlighting the relationships between a large number of drugs and enzymes. The book also highlights new prospects for therapeutic discoveries offered by enzyme targeting. Numerous applications have been developed thanks to strategies for studying enzyme inhibition or activation, as well as the development of allosteric effectors, presented with their advantages and disadvantages. Various rare diseases, known as "orphan" diseases, have resulted from enzyme deficiency or absence. For their treatment, the introduction of substitute enzymes has led to major therapeutic advances. 4aBiochemistry (Chemical Biology) 4aDrug Formulation & Delivery 4aEnzymes & Receptors00aenzyme dysfunction; biochemical reactions; drug science; enzyme targeting; enzyme inhibition; enzyme activation; rare diseases; substitute enzymes1 aDumond, Julien4aut08iPrinted edition:z978178630939640uhttps://doi.org/10.1002/9781394299096aWiley Online Library40uhttps://onlinelibrary.wiley.com/action/showBook?doi=10.1002%2F9781394299096aWiley Online Library423Cover Imageuhttps://onlinelibrary.wiley.com/cms/asset/7ca44103-0da4-471c-9a5b-7f2a9171a632/9781394299096.cover.gifaWiley Online Library