03015nam a22003734u 450000100220000000300060002200500170002800700150004500800410006002000300010102400310013104100080016210000280017024501130019825000060031126000160031726400160033330000120034933600260036133700260038733800360041334700210044934700080047052016440047865000480212265000290217065000500219970000310224977600360228085600640231685601020238085601420248299900170262410.1002/9781394207145Wiley20251030120309.0cr nn 008mam|a230906t2023||||xxu    fs|   |0|| 0|eng||  a9781394207145qelectronic7 a10.1002/97813942071452doi  aeng1 aCorey, E.J.4aut99166410aMolecules Engineered Against Oncogenic Proteins and Cancerh[electronic resource]cE.J. Corey, Yong‐Jin Wu  a1  bWileyc2023 1bWileyc2023  a400pp.;  atextbtxt2rdacontent  acomputerbc2rdamedia  aonline resourcebcr2rdacarrier  atext file2rdaft  bPDF  aMolecules Engineered Against Oncogenic Proteins and Cancer A comprehensive review of the latest molecular advances in cancer treatment Featuring 91 total small molecule kinase/KRAS inhibitors, 80 of which are FDA-approved, Molecules Engineered Against Oncogenic Proteins and Cancer documents the recent scientific advances that have transformed one of medicine's most challenging areas-cancer treatment. Most of these inhibitors specifically block oncogene-induced carcinogenic proteins with results that have dramatically advanced the treatment of cancer. In addition, the structural formulas of more than 100 kinase/KRAS inhibitors in clinical trials are presented. With a very well-known chemist as an author, Molecules Engineered Against Oncogenic Proteins and Cancer includes information on: Each molecule's structure, function of the kinase target and relevance to cancer, the drug discovery process, and molecular details of drug action Mutated protein kinases as oncoproteins and targets for inhibition, along with the details of discovery for each antitumor antikinase agent History of oncoprotein inhibitors and their role in advancing the treatment and understanding of cancer The discovery process as a whole, effective strategies for innovation, ongoing challenges, and a glimpse of the future of the field Combining the most significant recent discoveries in a unique and useful way, Molecules Engineered Against Oncogenic Proteins and Cancer is an essential resource for researchers and students in bioscience, medicine, chemistry, and oncology as well as for those at industrial companies involved in therapeutic discovery. 4aPharmaceutical & Medicinal Chemistry991083 4aOrganic Chemistry965327 4aPharmacology & Pharmaceutical Medicine9913161 aWu, Yong‐Jin4aut99166508iPrinted edition:z978139420708440uhttps://doi.org/10.1002/9781394207145aWiley Online Library40uhttps://onlinelibrary.wiley.com/action/showBook?doi=10.1002%2F9781394207145aWiley Online Library423Cover Imageuhttps://onlinelibrary.wiley.com/cms/asset/3a9e77ae-6f36-484a-a00e-1d411a636079/9781394207145.cover.gifaWiley Online Library  c67030d67030