03715nam a22003614u 450000100220000000300060002200500170002800700150004500800410006002000300010102400310013104100080016210000260017024500940019625000060029026000160029626400160031230000120032833600260034033700260036633800360039234700210042834700080044952022250045765000410268265000170272365000430274065302260278377600360300985600640304585601020310985601420321110.1002/9781394274086Wiley20251030120310.0cr nn 008mam|a240826t2024||||xxu    fs|   |0|| 0|eng||  a9781394274086qelectronic7 a10.1002/97813942740862doi  aeng1 aDemetzos, Costas4aut10aNanotechnology in TherapeuticsbBasics and Trendsh[electronic resource]cCostas Demetzos  a1  bWileyc2024 1bWileyc2024  a304pp.;  atextbtxt2rdacontent  acomputerbc2rdamedia  aonline resourcebcr2rdacarrier  atext file2rdaft  bPDF  aNanotechnology in Therapeutics Comprehensive reference delivering a framework to develop and assess nanosystems that provide unique advantages in biomedical applications Nanotechnology in Therapeutics explores the idea that by studying in depth the behavior of living organisms, especially the functionality of their cell membranes, we can develop and evaluate innovative bio-inspired nanosystems that are able to deliver small molecules, biomolecules like proteins, peptides, and other genetic material in terms of the production of new therapies and vaccines. The main concept promoted in this book is an integrated approach for producing new medicines following the nanotoxicity, biotoxicity, regulatory, and ethical guidelines, which are also covered in the book. The book is divided into three parts. Part A provides an introduction and a historical overview of nanotechnology. Part B delves deeper into issues relating to lipid and polymeric nanostructures in medicine. Part C presents the regulatory landscape around nanotechnology and nanomedicine, while highlighting the need to keep an eye on emerging technologies such as artificial intelligence and machine learning. Overall, this book opens up biomedical applications for previously challenging drugs and drug targets. Written by a highly qualified professor with significant pertinent research experience, Nanotechnology in Therapeutics includes discussion on: Eukaryotic cell membranes, their structural properties, and the thermodynamic payload of their lipid bilayers The DLVO (Derjaguin, Landau, Verwey and Overbeek) theory as a scientific tool for studying the stability and the behavior of nanoparticles Liposomes, lipid nanoparticles, and solid lipid nanoparticles, as well as polymeric nanoparticles, like micelles, polymersomes, and dendrimers Issues in the approval process of nanomedicines by the regulatory agencies, such as complexity, chaos, and nonlinear dynamics With comprehensive coverage of novel concepts that have the potential to transform how new medicines are designed and developed, Nanotechnology in Therapeutics is an essential resource on the subject for chemists in industry, as well as biomedical and pharmaceutical engineers. 4aPharmaceutical & Medicinal Chemistry 4aNanomedicine 4aPharmacology & Pharmaceutical Medicine00avaccine development; covid vaccines; drug design; drug development; therapeutics; Liposomes; lipid nanoparticles; polymeric nanoparticles; micelles; polymersomes; dendrimers; nanotoxicity; biotoxicity; medicine regulation08iPrinted edition:z978139427405540uhttps://doi.org/10.1002/9781394274086aWiley Online Library40uhttps://onlinelibrary.wiley.com/action/showBook?doi=10.1002%2F9781394274086aWiley Online Library423Cover Imageuhttps://onlinelibrary.wiley.com/cms/asset/04ff20cb-0aa4-4eb1-a9f9-6ed894eabd83/9781394274086.cover.gifaWiley Online Library