03412nam a22004334u 450000100220000000300060002200500170002800700150004500800410006002000300010102400310013104100080016224501900017025000060036026000160036626400160038230000120039833600260041033700260043633800360046234700210049834700080051949000500052752015720057765000330214965000170218265000440219965302080224370000270245170000280247870000270250670000270253370000240256077600360258483000500262085600640267085601020273485601420283610.1002/9783527840458Wiley20251030120311.0cr nn 008mam|a240705t2024||||xxu    fs|   |0|| 0|eng||  a9783527840458qelectronic7 a10.1002/97835278404582doi  aeng00aRNA as a Drug TargetbThe Next Frontier for Medicinal Chemistryh[electronic resource]cEdited by John Schneekloth, Martin Pettersson, Raimund Mannhold, Helmut Buschmann, Jörg Holenz.  a1  bWileyc2024 1bWileyc2024  a416pp.;  atextbtxt2rdacontent  acomputerbc2rdamedia  aonline resourcebcr2rdacarrier  atext file2rdaft  bPDF1 aMethods and Principles in Medicinal Chemistry  aDiscover a new paradigm in drug discovery that greatly expands the space of addressable drug targets and potential novel drugs Existing paradigms for drug discovery have focused largely on enzymes and other proteins as drug targets. In recent years, however, different varieties of ribonucleic acids have emerged as a viable focus for target-based drug discovery, with the potential to revolutionize the strategy and approach for this essential step in the drug development process. RNA as a Drug Target: The Next Frontier for Medicinal Chemistry offers a practice-oriented introduction to developing drug-like small molecules that selectively modulate both coding and non-coding RNAs. Beginning with a description and characterization of existing druggable RNAs, the book discusses how to approach different RNA targets for drug discovery. The result is a crucial resource for targeting RNAs and creating the next generation of life-saving pharmaceuticals. RNA as a Drug Target readers will also find: A complete "toolbox" for working with RNA, from structure determination to screening and lead generation techniques A wide range of addressable targets and mechanisms, including splicing modulation, riboswitches, targeted degradation, and more Authoritative discussion of the potential of RNA-targeted small molecule therapeutics for drugging the epitranscriptome RNA as a Drug Target provides an expert introduction to a new frontier in pharmaceutical research for medicinal chemists, biochemists, molecular biologists, and members of the pharmaceutical industry. 4aDrug Discovery & Development 4aBiochemistry 4aBiomolecules (DNA, RNA, Peptides, etc.)00aProteins; regulatory RNA; drug developer; undruggable disease; ribonucleic acid; enzyme; receptor; drug target; new therapeutics; medical chemist; biochemist; molecular biologist; pharmaceutical industry1 aSchneekloth, John4edt1 aPettersson, Martin4edt1 aMannhold, Raimund4edt1 aBuschmann, Helmut4edt1 aHolenz, Jörg4edt08iPrinted edition:z9783527351008 0aMethods and Principles in Medicinal Chemistry40uhttps://doi.org/10.1002/9783527840458aWiley Online Library40uhttps://onlinelibrary.wiley.com/action/showBook?doi=10.1002%2F9783527840458aWiley Online Library423Cover Imageuhttps://onlinelibrary.wiley.com/cms/asset/d9f541f8-0390-4132-86af-33a205ae917d/9783527840458.cover.gifaWiley Online Library