03548nam a22004574u 4500 10.1002/9783527840458 Wiley 20251030120311.0 cr nn 008mam|a 240705t2024||||xxu fs| |0|| 0|eng|| 9783527840458 electronic 10.1002/9783527840458 doi eng RNA as a Drug Target The Next Frontier for Medicinal Chemistry [electronic resource] Edited by John Schneekloth, Martin Pettersson, Raimund Mannhold, Helmut Buschmann, Jörg Holenz. 1 Wiley 2024 Wiley 2024 416pp.; text txt rdacontent computer c rdamedia online resource cr rdacarrier text file rdaft PDF Methods and Principles in Medicinal Chemistry Discover a new paradigm in drug discovery that greatly expands the space of addressable drug targets and potential novel drugs Existing paradigms for drug discovery have focused largely on enzymes and other proteins as drug targets. In recent years, however, different varieties of ribonucleic acids have emerged as a viable focus for target-based drug discovery, with the potential to revolutionize the strategy and approach for this essential step in the drug development process. RNA as a Drug Target: The Next Frontier for Medicinal Chemistry offers a practice-oriented introduction to developing drug-like small molecules that selectively modulate both coding and non-coding RNAs. Beginning with a description and characterization of existing druggable RNAs, the book discusses how to approach different RNA targets for drug discovery. The result is a crucial resource for targeting RNAs and creating the next generation of life-saving pharmaceuticals. RNA as a Drug Target readers will also find: A complete "toolbox" for working with RNA, from structure determination to screening and lead generation techniques A wide range of addressable targets and mechanisms, including splicing modulation, riboswitches, targeted degradation, and more Authoritative discussion of the potential of RNA-targeted small molecule therapeutics for drugging the epitranscriptome RNA as a Drug Target provides an expert introduction to a new frontier in pharmaceutical research for medicinal chemists, biochemists, molecular biologists, and members of the pharmaceutical industry. Drug Discovery & Development 91621 Biochemistry 65465 Biomolecules (DNA, RNA, Peptides, etc.) 91323 Proteins; regulatory RNA; drug developer; undruggable disease; ribonucleic acid; enzyme; receptor; drug target; new therapeutics; medical chemist; biochemist; molecular biologist; pharmaceutical industry Schneekloth, John edt 91773 Pettersson, Martin edt 91774 Mannhold, Raimund edt 91775 Buschmann, Helmut edt 91776 Holenz, Jörg edt 91777 Printed edition: 9783527351008 Methods and Principles in Medicinal Chemistry 91626 https://doi.org/10.1002/9783527840458 Wiley Online Library https://onlinelibrary.wiley.com/action/showBook?doi=10.1002%2F9783527840458 Wiley Online Library Cover Image https://onlinelibrary.wiley.com/cms/asset/d9f541f8-0390-4132-86af-33a205ae917d/9783527840458.cover.gif Wiley Online Library 67083 67083