02273nam a22003614u 450000100220000000300060002200500170002800700150004500800410006002000300010102400310013104100080016210000380017024500980020825000060030626000160031226400160032830000120034433600260035633700260038233800360040834700210044434700080046552009200047365000510139365000450144465000310148965300940152077600360161485601020165085601420175299900170189410.1002/9781394264902Wiley20251030120317.0cr nn 008mam|a231229t2023||||xxu    fs|   |0|| 0|eng||  a9781394264902qelectronic7 a10.1002/97813942649022doi  aeng1 aRichard, Guy‐Franck4aut99207710aFunction and Evolution of Repeated DNA Sequencesh[electronic resource]cGuy‐Franck Richard  a1  bWileyc2023 1bWileyc2023  a400pp.;  atextbtxt2rdacontent  acomputerbc2rdamedia  aonline resourcebcr2rdacarrier  atext file2rdaft  bPDF  aThe genome of a living being is composed of DNA sequences with diverse origins. Beyond single-copy genes, whose product has a biological function that can be inferred by experimentation, certain DNA sequences, present in a large number of copies, escape the most refined approaches aimed at elucidating their precise role. The existence of what 20th century geneticists had already perceived (and wrongly described as "junk DNA"!) was confirmed by the sequencing of the first complex genomes, including that of Homo sapiens. A large part of what defines a living thing is not unique, but repeated, sometimes a very large number of times, increasing in complexity with successive duplications and multiplication. Understanding and defining the many functions of this myriad of repeated sequences, as well as their evolution through natural selection, has become one of the major challenges for 21st century genomics. 4aBiomolecules (DNA, RNA, Peptides, etc.)991323 4aMolecular Biology (Life Sciences)992078 4aMolecular Evolution98105300agenome; DNA; DNA sequences; genetics; single-copy genes; junk DNA; repeated DNA sequences08iPrinted edition:z978178945119140uhttps://onlinelibrary.wiley.com/action/showBook?doi=10.1002%2F9781394264902aWiley Online Library423Cover Imageuhttps://onlinelibrary.wiley.com/cms/asset/c965d19f-8af5-49d2-9ad6-9da5f3c74578/9781394264902.cover.gifaWiley Online Library  c67207d67207