03603cam a2200565Ki 4500 9781315165646 FlBoTFG 20251030122307.0 m o d cr cnu|||unuuu 211007s2022 xx o 000 0 eng d OCoLC-P eng rda pn OCoLC-P 9781315165646 (electronic bk.) 1315165643 (electronic bk.) 9781351677714 (electronic bk. : Mobipocket) 1351677713 (electronic bk. : Mobipocket) 9781351677721 (electronic bk. : EPUB) 1351677721 (electronic bk. : EPUB) 9781032203300 9781351677738 (electronic bk. : PDF) 135167773X (electronic bk. : PDF) 9781138055902 (OCoLC)1273727421 (OCoLC-P)1273727421 QP93.5 MED 008000 bisacsh MED 071000 bisacsh SCI 049000 bisacsh PSD bicssc Lundblad, Roger L. Lundblad Biotechnology, Chapel Hill, North Carolina, USA. 96146 The Chemical Biology of Thrombin. First edition. [Place of publication not identified] : CRC Press, 2022. 1 online resource (300 pages). text txt rdacontent computer c rdamedia online resource cr rdacarrier Chapter 1The History of ThrombinChapter 2The Formation of ThrombinChapter 3Structural Biology of ThrombinChapter 4The use of Protein Engineering (Mutagenesis) to Study Functional Regions in ThrombinExpression and Characterization of Recombinant ThrombinsChapter 5Chemical Modification of ThrombinChapter 6The Interaction of Thrombin with Fibrinogen and FibrinChapter 7Thrombin and PlateletsChapter 8Inhibitors of Thrombin This book is a comprehensive review of thrombin, especially as regulatory protease. The ready availability of highly purified thrombin has stimulated rapid advances in the cell biology of this important macromolecule. The text focuses on research findings from the discovery of thrombin by Andrew Buchanan in 1842 to the present. A substantial amount of this work was conducted by the author and his colleagues. His work on the purification of thrombin was seminal to much subsequent work on thrombin. This volume provides a framework for future studies now made possible by the discovery of the importance of exosites in the physiology of thrombin function. The current work describes the process of the development of an oral inhibitor of thrombin used in the prevention of thrombosis. Key Features Reviews the history of Thrombin (Fibrin Ferment) Documents the relation of protein engineering and chemical modification in the study of thrombin Summarizes the interaction of thrombin with fibrinogen and fibrin Outlines the role of exosites in thrombin function Describes the development of an oral inhibitor for thrombin OCLC-licensed vendor bibliographic record. Thrombin. 96147 MEDICAL / Biochemistry bisacsh 67828 MEDICAL / Pharmacology bisacsh 64250 SCIENCE / Life Sciences / Biology / Molecular Biology bisacsh 64014 Taylor & Francis https://www.taylorfrancis.com/books/9781315165646 OCLC metadata license agreement http://www.oclc.org/content/dam/oclc/forms/terms/vbrl-201703.pdf E-Books 68283 68283