03520cam a2200541Ki 45000010014000000030008000140050017000220060019000390070015000580080041000730400035001140200036001490200033001850200049002180200046002670200043003130200040003560200018003960200042004140200039004560200018004950350022005130350024005350500011005590720025005700720025005950720025006200720016006451000089006612450038007502500019007882640063008073000035008703360026009053370026009313380036009575050426009935201128014195880047025476500021025946500043026156500043026586500074027018560072027758560102028479420012029499990017029619781315165646FlBoTFG20251030122307.0m     o  d        cr cnu|||unuuu211007s2022    xx      o     000 0 eng d  aOCoLC-PbengerdaepncOCoLC-P  a9781315165646q(electronic bk.)  a1315165643q(electronic bk.)  a9781351677714q(electronic bk. : Mobipocket)  a1351677713q(electronic bk. : Mobipocket)  a9781351677721q(electronic bk. : EPUB)  a1351677721q(electronic bk. : EPUB)  z9781032203300  a9781351677738q(electronic bk. : PDF)  a135167773Xq(electronic bk. : PDF)  z9781138055902  a(OCoLC)1273727421  a(OCoLC-P)1273727421 4aQP93.5 7aMEDx0080002bisacsh 7aMEDx0710002bisacsh 7aSCIx0490002bisacsh 7aPSD2bicssc1 aLundblad, Roger L.uLundblad Biotechnology, Chapel Hill, North Carolina, USA.99614614aThe Chemical Biology of Thrombin.  aFirst edition. 1a[Place of publication not identified] :bCRC Press,c2022.  a1 online resource (300 pages).  atextbtxt2rdacontent  acomputerbc2rdamedia  aonline resourcebcr2rdacarrier0 aChapter 1The History of ThrombinChapter 2The Formation of ThrombinChapter 3Structural Biology of ThrombinChapter 4The use of Protein Engineering (Mutagenesis) to Study Functional Regions in ThrombinExpression and Characterization of Recombinant ThrombinsChapter 5Chemical Modification of ThrombinChapter 6The Interaction of Thrombin with Fibrinogen and FibrinChapter 7Thrombin and PlateletsChapter 8Inhibitors of Thrombin  aThis book is a comprehensive review of thrombin, especially as regulatory protease. The ready availability of highly purified thrombin has stimulated rapid advances in the cell biology of this important macromolecule. The text focuses on research findings from the discovery of thrombin by Andrew Buchanan in 1842 to the present. A substantial amount of this work was conducted by the author and his colleagues. His work on the purification of thrombin was seminal to much subsequent work on thrombin. This volume provides a framework for future studies now made possible by the discovery of the importance of exosites in the physiology of thrombin function. The current work describes the process of the development of an oral inhibitor of thrombin used in the prevention of thrombosis. Key Features Reviews the history of Thrombin (Fibrin Ferment) Documents the relation of protein engineering and chemical modification in the study of thrombin Summarizes the interaction of thrombin with fibrinogen and fibrin Outlines the role of exosites in thrombin function Describes the development of an oral inhibitor for thrombin  aOCLC-licensed vendor bibliographic record. 0aThrombin.996147 7aMEDICAL / Biochemistry2bisacsh967828 7aMEDICAL / Pharmacology2bisacsh964250 7aSCIENCE / Life Sciences / Biology / Molecular Biology2bisacsh964014403Taylor & Francisuhttps://www.taylorfrancis.com/books/9781315165646423OCLC metadata license agreementuhttp://www.oclc.org/content/dam/oclc/forms/terms/vbrl-201703.pdf  cE-Books  c68283d68283