07835nam a2200829 i 4500 9780750340038 IOP 20251030124213.0 m eo d cr cn |||m|||a 231201s2023 enka fob 000 0 eng d 9780750340038 ebook 9780750340021 mobi 9780750340014 print 9780750340045 myPrint 10.1088/978-0-7503-4003-8 doi (CaBNVSL)thg00083689 (OCoLC)1412322821 CaBNVSL eng rda CaBNVSL CaBNVSL RC262 .M547 2023eb vol. 4 QZ 203 M632p 2023eb vol. 4 PHVN bicssc SCI009000 bisacsh Mierke, Claudia Tanja, author. 96509 Physics of cancer. Volume 4, Mechanical characterization of cells / Claudia Tanja Mierke. Mechanical characterization of cells. Second edition. Bristol [England] (Temple Circus, Temple Way, Bristol BS1 6HG, UK) : IOP Publishing, [2023] 1 online resource (various pagings) : illustrations (some color). text rdacontent electronic isbdmedia online resource rdacarrier [IOP release $release] Biophysical Society-IOP series IOP ebooks. [2023 collection] "Version: 20231101"--Title page verso. Includes bibliographical references. 1. Mechanosensing and the mechanotransduction of cells -- 1.1. An introduction to mechanosensation and mechanotransduction in living cells -- 1.2. Molecular mechanosensory behavior -- 1.3. The role of focal adhesion proteins -- 1.4. Interplay between mechanosensors -- 1.5. The interplay between focal adhesion proteins and cell-matrix receptors -- 1.6. The interplay between focal adhesion proteins and cell-cell adherence junctions -- 1.7. Force detection and transduction at adherens junctions -- 1.8. The transfer of mechanical forces at the cadherin-catenin complex -- 1.9. The role of the cytoskeleton -- 1.10. The role of the nucleus in sensing mechanical cues -- 1.11. Restrained mechanosensing in cancer -- 1.12. The regulation of gene expression in mechanotransduction in cancer cells -- 1.13. Alterations of the extracellular matrix environment in cancerous diseases -- 1.14. Conclusions and future perspectives 2. Overview and discussion of biophysical techniques for the mechanical characterization of cell nuclei and cells -- 2.1. Introduction to biophysical techniques used for the mechanical characterization of the nuclei of living cells -- 2.2. Analysis of nuclear positioning in a living cell -- 2.3. Analysis of the nuclear mechanical characteristics -- 2.4. Components of the nuclear framework contribute to mechanosensing -- 2.5. Analyses of nuclear mechanics -- 2.6. Analysis of the cytoskeleton and cell cortex -- 2.7. A critical discussion of mechanical measurements of living cells -- 2.8. A discussion of the selection of a specific biophysical technique -- 2.9. Conclusions and future research 3. Overview and discussion of biophysical techniques for the mechanical characterization of plasma membranes -- 3.1. A concise introduction to plasma membrane models -- 3.2. Giant plasma membrane vesicles serve as a model for the plasma membrane -- 3.3. Biophysical analysis of the plasma membrane of cells -- 3.4. The principles of the dynamics of the plasma membrane -- 3.5. Models and theories of the plasma membrane -- 3.6. The heat theory of the plasma membrane -- 3.7. The phenomenon of bioelectricity -- 3.8. The main findings in cancer research related to the plasma membrane -- 3.9. The prominent role of the bioelectrical code -- 3.10. Are aging and cancer opposite or the same sides of the coin in terms of pathology? -- 3.11. Bioelectric signal transmission within the mechanical microenvironment -- 3.12. Deciphering the direction of the flow of communication : separating the mechanical microenvironment from the bioelectrical signaling -- 3.13. Conclusions and future research 4. A survey of biophysical techniques used for the mechanical characterization of cell spheroids, organoids, and tumoroids -- 4.1. An overview of multicellular culture models -- 4.2. Tissue explants -- 4.3. Cell cluster formation and cell aggregates -- 4.4. Cell spheroids -- 4.5. Organoids -- 4.6. The effect of organoid vascularization -- 4.7. Tumoroids -- 4.8. Mechanical measurements of cell clusters, spheroids, organoids, or tumoroids -- 4.9. The effects of cell sorting and invasion -- 4.10. A discussion of the advantages and disadvantages of cell aggregate mechanical analyses -- 4.11. Conclusions and future research. This is the fourth volume of the highly regarded Physics of Cancer (Second Edition) series, written with the aim of making very important topics in the physics of cancer visible to the research community. This fourth volume deals with mechanobiology using biophysical methods. The first chapter deals with mechanosensing and mechanotransduction on vastly different length scales. The second chapter discusses biophysical techniques for mechanical phenotype characterization of cells and nuclei. The third provides an overview of the mechanical phenotype of the plasma membrane. The fourth chapter contains the latest insights into the mechanical assessment of cell spheroids, organoids and tumoroids. The basic approach of this text is to present the latest promising findings to the scientific community, addressing scientists at all career stages. Part of Biophysical Society-IOP series. Scientists, researchers, graduate students, instructors in biophysics. Also available in print. Mode of access: World Wide Web. System requirements: Adobe Acrobat Reader, EPUB reader, or Kindle reader. Claudia Tanja Mierke is Head of the Department of Biological Physics at the Peter Debye Institute for Soft Matter Physics at Leipzig University. Her primary research areas are cell biophysics and cell mechanics, adhesion, motility (invasion) in biomimetic matrices, cancer and inflammation, cancer metastasis and tumor microenvironment mechanics. She has published over 150 refereed journal articles, books and book chapters largely dealing with soft matter physics and the physics of cancer. Over the past 18 years, Claudia had taught courses in biophysics, soft matter physics, cell biology for physicists and cellular biophysics, to both undergraduate and graduate students. Title from PDF title page (viewed on December 1, 2023). Biophysics. 66239 Pathology, Molecular. 96510 Cell physiology. 96511 Cell Transformation, Neoplastic. 96512 Cell Physiological Phenomena. 96513 Tumor Microenvironment. 96514 Biomechanical Phenomena. 96515 Neoplasms. 63724 Biophysics. 66239 Pathology, Molecular. 96510 Biophysics. bicssc 66239 SCIENCE / Life Sciences / Biophysics. bisacsh 95352 Cancer cells Mechanical properties. 96516 Cancer. 4311 Institute of Physics (Great Britain), publisher. 17702 Print version: 9780750340014 9780750340045 IOP (Series). Release 23. Biophysical Society-IOP series. 96362 IOP ebooks. 2023 collection. https://iopscience.iop.org/book/mono/978-0-7503-4003-8 E-Books 68367 68367