TY - BOOK AU - Keidar,Michael AU - Yan,Dayun AU - Lin,Li ED - Institute of Physics (Great Britain), TI - Cold atmospheric plasma-based cancer therapy T2 - [IOP release $release] SN - 9780750355377 AV - RC271.L68 K453 2023eb PY - 2023///] CY - Bristol [England] (Temple Circus, Temple Way, Bristol BS1 6HG, UK) PB - IOP Publishing KW - Cancer KW - Treatment KW - Low temperature plasmas KW - Therapeutic use KW - Neoplasms KW - therapy KW - Plasma Gases KW - therapeutic use KW - Plasma physics KW - bicssc KW - SCIENCE / Physics / Atomic & Molecular KW - bisacsh N1 - "Version: 20230901"--Title page verso; Revised edition of: Cold plasma cancer therapy; Includes bibliographical references; 1. Introduction to non-thermal plasma physics -- 1.1. Plasma -- 1.2. Plasma quasi-neutrality -- 1.3. Plasma oscillations -- 1.4. Particle collisions -- 1.5. Plasma types -- 1.6. Cold atmospheric plasmas (CAP) -- 1.7. CAP in plasma therapy; 2. Cold atmospheric plasma generators -- 2.1. Ionization -- 2.2. Cold atmospheric plasma; 3. Diagnostics and modeling of cold atmospheric plasmas -- 3.1. General overview of CAP diagnostics -- 3.2. Numerical simulation and modeling; 4. Chemically based cold atmospheric plasma treatment -- 4.1. Anti-cancer demonstration in vitro -- 4.2. Two treatment approaches -- 4.3. Anti-cancer mechanism; 5. Cold atmospheric plasma-activated solutions -- 5.1. Indirect CAP treatment -- 5.2. Effective components in PAS -- 5.3. Instability in storage; 6. Physics based cold atmospheric plasma therapy -- 6.1. Limitation of chemically-based treatment -- 6.2. Revealing physical effect -- 6.3. Necrotic cell death -- 6.4. Bubbling and osmotic pressure -- 6.5. Anti-cancer physical factors in CAP -- 6.6. Modulating physical effects -- 6.7. Trans barrier capability -- 6.8. Physical versus chemical treatment; 7. Selective anti-cancer performance -- 7.1. Selective anti-cancer effect -- 7.2. Selective anti-cancer mechanism -- 7.3. H2O2 channels : aquaporins (AQP) -- 7.4. Antioxidant system -- 7.5. Transient membrane pores -- 7.6. Singlet oxygen -- 7.7. Genomic repairing system -- 7.8. Novel selectivity concepts -- 7.9. Summary; 8. Animal studies and immune responses -- 8.1. Cutaneous CAP treatment -- 8.2. Intracranial models -- 8.3. Abscopal phenomena -- 8.4. Sensitization of tumor to drugs -- 8.5. Transdermal anti-tumor mechanism -- 8.6. Thermal effect -- 8.7. Immune responses; 9. Clinical perspectives -- 9.1. Clinical studies -- 9.2. Outlook; 10. Physics and technology of the adaptive plasma therapy -- 10.1. Plasma self-organization phenomena -- 10.2. Adaptive plasma devices -- 10.3. MPC-based adaptive plasma platform -- 10.4. Electrochemical response of cells to plasma : real-time impedance measurements -- 10.5. Adaptive plasma treatment based on machine learning technologies -- 10.6. Intelligent plasma based on self-organization patterns; Researchers in low temperature plasmas and cancer therapy; Also available in print N2 - With the unique chemical and physical properties of cold atmospheric plasmas enabling their recent applications in biomedicine, plasma medicine has established itself as a new scientific field, combining plasma physics, engineering, medicine, and bioengineering. This book provides a comprehensive introduction to the fundamentals of the non-thermal plasmas and plasma devices used in plasma medicine. Several chapters are devoted to the analysis of the mechanisms of plasma interaction with cancer and normal cells, including a description of the mechanism of plasma selectivity. As a revised and significantly expanded second edition, this text includes a detailed description of non-invasive modality, new in vivo work and adaptive plasma written by experts in these areas. This reference text also provides an up-to-date description of the field, the primary challenges and future directions. Part of IOP Series in Plasma Physics UR - https://iopscience.iop.org/book/mono/978-0-7503-5537-7 ER -