TY - BOOK AU - Robertson-Anderson,Rae M. ED - Institute of Physics (Great Britain), TI - Biopolymer networks: design, dynamics and discovery T2 - [IOP release $release] SN - 9780750350372 AV - QP801.B69 R633 2024eb PY - 2024///] CY - Bristol [England] (Temple Circus, Temple Way, Bristol BS1 6HG, UK) PB - IOP Publishing KW - Biopolymers KW - Polymer networks KW - Pre-clinical medicine - basic sciences KW - bicssc KW - MEDICAL / Biotechnology KW - bisacsh N1 - "Version: 20240801"--Title page verso; Includes bibliographical references; part I. Let's get started. 1. Introduction to biopolymers and their networks -- 1.1. Polymers 101 -- 1.2. Biopolymer basics -- 1.3. Biopolymer networks in biology -- 1.4. Biopolymer networks in physics and engineering -- 1.5. What next?; part II. Making sense and measuring. 2. Polymer physics for everyone -- 2.1. The beauty of polymer physics -- 2.2. Polymer flexibility -- 2.3. Single polymer conformations -- 2.4. Single polymer dynamics -- 2.5. Beyond the standard tube model -- 2.6. Rheology -- 2.7. Semiflexible polymers -- 2.8. Rigid rod polymers -- 2.9. Crosslinked polymer networks -- 2.10. Nonlinear viscoelasticity -- 2.11. To be continued; 3. Measuring mechanics, dynamics, and structure -- 3.1. Direct imaging of biopolymers -- 3.2. Direct measurements of force, stress, and dynamics -- 3.3. What's next; 4. Analysis methods, algorithms, and deliverables -- 4.1. Single-molecule center-of-mass tracking -- 4.2. Single-particle tracking (SPT) -- 4.3. Particle-image velocimetry (PIV) -- 4.4. Differential dynamic microscopy (DDM) -- 4.5. Spatial image autocorrelation -- 4.6. Advanced techniques and further reading; 5. Biopolymer network design, dynamics, and mechanics -- 5.1. DNA solutions : from dilute to highly entangled -- 5.2. Entangled and crosslinked actin networks -- 5.3. Entangled and crosslinked networks of microtubules -- 5.4. Intermediate filament (IF) networks -- 5.5. Canonical building blocks for complex biopolymer networks; part III. Beyond the basics--novel and complex networks. 6. Networks of topologically-novel biopolymers -- 6.1. Relaxed circular (ring) biopolymers -- 6.2. Supercoiled circular biopolymers -- 6.3. Concatenated ring biopolymers -- 6.4. Branched biopolymers -- 6.5. Building in complexity; 7. Biopolymer composites, blends, and crowding -- 7.1. Biopolymer blends -- 7.2. Biopolymer composites -- 7.3. Considerations and outlook; part IV. Spatiotemporal heterogeneity : from active matter to coacervates. 8. Active, responsive, and reconfigurable networks -- 8.1. Motor-driven cytoskeleton networks -- 8.2. Chemically-triggered biopolymer networks -- 8.3. Non-equilibrium DNA networks -- 8.4. Considerations and outlook; 9. Self-assembly and phase separation -- 9.1. Beyond local heterogeneity -- 9.2. Introduction to liquid-liquid phase separation (LLPS) -- 9.3. Crowding and liquid-liquid phase separation -- 9.4. Complex coacervates -- 9.5. LLPS of intrinsically disordered proteins -- 9.6. LLPS of nucleic acids -- 9.7. Structurally heterogeneous condensates -- 9.8. Active and dynamic liquid-liquid phase separation -- 9.9. Viscoelastic phase separation (VPS) -- 9.10. Considerations and outlook; part V. What now? 10. Past, present, and future : perspectives from the community -- 10.1. What we have learned -- 10.2. What we are still learning -- 10.3. Who 'we' are and what we think -- 10.4. What are the big open questions in the field of biopolymer networks? -- 10.5. What is needed in the research community to make advances in the field? -- 10.6. What is a 'must-read' for anyone interested in learning more about the field?; Full-text restricted to subscribers or individual document purchasers; This book will be a must read for researchers, academics (graduate students, postdocs, professors, research scientists, etc) and industry professionals in the fields of biophysics, soft and active matter, polymer physics, cellular biology, materials science, physical chemistry, and biomaterials engineering. The text will be written with this interdisciplinary audience in mind and will be the go-to resource for both seasoned researchers and those looking to enter the field. This text will also be accessible to undergraduates with upper division physics or biophysics training and could be used in graduate level courses in physics, biophysics, bioengineering and materials science programs; Also available in print N2 - This reference text provides a broad overview of biopolymer networks written for an interdisciplinary audience of cellular and molecular biologists, soft matter and polymer physicists, materials scientists, and chemical engineers. It opens with an introduction to biopolymers and their networks, followed by an overview of important polymer physics theories and concepts, experimental tools to measure network properties, and computational analysis techniques to characterize and interpret data. The book follows with a description of model biopolymer networks--from design to rheology--before embarking on a discussion of novel network designs and their emergent physical properties, including topologically-novel polymers, composites, active matter, and liquid-liquid phase separation. It closes with a community-led perspective on key open questions and grand challenges, and how we may come together to advance understanding of biopolymer networks and their utility in diverse applications. Part of Biophysical Society-IOP series UR - https://iopscience.iop.org/book/mono/978-0-7503-5037-2 ER -