11949nam a2200817 i 45000010014000000030004000140050017000180060019000350070015000540080041000690200025001100200024001350200025001590200027001840240035002110350025002460350022002710400040002930500031003330600032003640720016003960720023004121000039004352450148004742460042006222500020006642640098006843000071007823360021008533370026008743380032009004900027009324900034009595000043009935040041010365050598010775050639016755050579023145050530028935050707034235050675041305050455048055051230052605050711064905050452072015060075076535200803077285210117085315300029086485380036086775380078087135451660087915880059104516500041105106500031105516500027105826500026106096500032106356500026106676500034106936500045107277000037107727000059108097100061108687760049109298300031109788300034110098560059110439420012111029990017111149780750353878IOP20251030124829.0m    eo  d        cr cn |||m|||a241003s2024    enka   fob    000 0 eng d  a9780750353878qebook  a9780750353861qmobi  z9780750353854qprint  z9780750353885qmyPrint7 a10.1088/978-0-7503-5387-82doi  a(CaBNVSL)thg00083985  a(OCoLC)1458668809  aCaBNVSLbengerdacCaBNVSLdCaBNVSL 4aRS380b.B535 2024eb vol. 2 4aQV 778bB575i 2024eb vol. 3 7aTCB2bicssc 7aMED0090002bisacsh1 aAl-Harrasi, Ahmed,eauthor.9969901 aIntroduction to pharmaceutical biotechnology.nVolume 2,pEnzymes, proteins and bioinformatics /cAhmed Al-Harrasi, Saurabh Bhatia, Ajmal Khan.3 aEnzymes, proteins and bioinformatics.  aSecond edition. 1aBristol [England] (Temple Circus, Temple Way, Bristol BS1 6HG, UK) :bIOP Publishing,c[2024]  a1 online resource (various pagings) :billustrations (some color).  atext2rdacontent  aelectronic2isbdmedia  aonline resource2rdacarrier1 a[IOP release $release]1 aIOP ebooks. [2024 collection]  a"Version: 20240901"--Title page verso.  aIncludes bibliographical references.8 a3. Industrial enzymes and their applications -- 3.1. Industrial enzymes -- 3.2. Bacterial [alpha]-amylases -- 3.3. Fungal [alpha]-amylases -- 3.4. Bacterial proteases -- 3.5. Fungal proteases -- 3.6. Glucose isomerase (d-xylose ketol-isomerase; EC. 5.3.1.5) -- 3.7. Penicillinase -- 3.8. Chloramphenicol acetyltransferase -- 3.9. Aminoglycoside antibiotic inactivating enzymes -- 3.10. Fibrinolytic enzymes -- 3.11. Biotechnological applications of enzymes -- 3.12. Industrial enzymes -- 3.13. The role of enzymes in the synthesis of functional foods -- 3.14. Enzymes used as additives to food8 a4. Immobilization of enzymes -- 4.1. Introduction -- 4.2. Types of immobilization -- 4.3. Genetic engineering for microbial enzyme production -- 4.4. Protein studies for modification of commercial enzymes -- 4.5. Enzyme and cell immobilization -- 4.6. Immobilization methods -- 4.7. Choice of immobilization technique -- 4.8. Immobilization of cells -- 4.9. Manufacture of commercial products -- 4.10. Immobilized enzymes for biomedical applications -- 4.11. Detecting biomass with immobilized cells via bioluminescence and other biosensor uses -- 4.12. Bioluminescence-based microbial biosensors -- 4.13. Immobilization of microalgae8 a5. Biosensors -- 5.1. Introduction -- 5.2. Principles of a biosensor -- 5.3. Different types of biosensors -- 5.4. Applications of biosensors -- 5.5. Recent advancements in biosensor technology -- 5.6. Microbial biosensors utilizing synthetic biology and genetic/protein engineering techniques -- 5.7. Technological comparison of biosensors -- 5.8. Prospective challenges, and inherent limitations associated with biosensor technology -- 5.9. Grand challenges in biosensors and biomolecular electronics -- 5.10. The Implementation and commercialization of biosensing devices8 a6. Biotransformation and enzymes -- 6.1. Introduction -- 6.2. Types of biotransformation reactions -- 6.3. Sources of biocatalysts and techniques for biotransformation -- 6.4. Product recovery in biotransformations -- 6.5. Application of biotransformation in the production of pharmaceutical products -- 6.6. Mechanisms of enzyme action in biotransformation -- 6.7. Biotransformation in environmental applications -- 6.8. Emerging technologies in biotransformation -- 6.9. Biotransformation challenges and future perspectives8 a7. Introduction to genomics -- 7.1. Introduction -- 7.2. Characterizations in genomics -- 7.3. Historical background -- 7.4. Genome sequencing -- 7.5. Understanding bioinformatics and sequencing -- 7.6. Comparative genomics as a technique to understand evolution -- 7.7. Gene estimation and counting -- 7.8. Genomes : genome evolution -- 7.9. Algae bioinformatics -- 7.10. Functional genomics -- 7.11. Structural genomics -- 7.12. Epigenomics and epigenetics -- 7.13. Pharmacogenomics -- 7.14. Population genomics -- 7.15. Microbiome genomics -- 7.16. Synthetic biology and genome editing -- 7.17. Systems biology and genomics -- 7.18. Genome-wide association studies (GWAS) -- 7.19. Future of genomics8 a8. Basics of proteomics -- 8.1. Introduction -- 8.2. Types of proteomics -- 8.3. Basic techniques involved in proteomics -- 8.4. Complete proteome of Mycoplasma genitalium -- 8.5. Architecture and design of the nuclear pore complex -- 8.6. Functional genomics and systems biology -- 8.7. Synthetic genomics -- 8.8. Advanced techniques in proteomics -- 8.9. Proteogenomics -- 8.10. Single-cell proteomics -- 8.11. Clinical and diagnostic proteomics -- 8.12. Metaproteomics -- 8.13. Emerging topics in proteomics -- 8.14. Ethical and data management issues in proteomics -- 8.15. Cellular and molecular dynamics -- 8.16. Membrane proteomics -- 8.17. Subcellular proteomics8 a9. Bioinformatics -- 9.1. Introduction -- 9.2. History of bioinformatics -- 9.3. Sequences and nomenclature -- 9.4. Investigation by means of bioinformatics tools -- 9.5. Computational approaches in bioinformatics -- 9.6. Bioinformatics in precision medicine -- 9.7. Translational bioinformatics -- 9.8. Bioinformatics in drug discovery and development -- 9.9. CRISPR and genome editing in bioinformatics -- 9.10. Integrative and multi-omics analysis8 a10. Protein and enzyme engineering -- 10.1. Protein and enzyme engineering -- 10.2. Designing macromolecules -- 10.3. Protein engineering versus enzyme engineering -- 10.4. Protein engineering -- 10.5. Foundation of protein (enzyme) engineering -- 10.6. Basic assumptions for protein engineering -- 10.7. Steps involved in protein engineering -- 10.8. Methods of protein engineering -- 10.9. Mutagenesis and selection of mutant enzymes -- 10.10. Gene modifications or gene synthesis for protein engineering -- 10.11. Multi-enzyme systems -- 10.12. Chemical modification of enzyme -- 10.13. Some early achievements of protein engineering -- 10.14. Computational approaches in protein engineering -- 10.15. Directed evolution techniques -- 10.16. Post-translational modifications -- 10.17. Structural flexibility and allosteric regulation -- 10.18. Protein-protein and protein-ligand interactions -- 10.19. Applications in synthetic biology -- 10.20. Engineering multi-functional proteins -- 10.21. Ethical and safety considerations -- 10.22. Studies in protein engineering -- 10.23. Single-molecule techniques in protein engineering -- 10.24. High throughput screening methods -- 10.25. Protein engineering for nanotechnology.  a1. Introduction to enzymes and their applications -- 1.1. Introduction -- 1.2. Properties of enzymes -- 1.3. Catalysis -- 1.4. The structure of enzymes -- 1.5. Structural features : primary and secondary structures -- 1.6. Nomenclature and classification -- 1.7. The mechanism of action of enzymes -- 1.8. Catalysis via chymotrypsin -- 1.9. Enzyme inhibition -- 1.10. Pharmaceutical applications -- 1.11. Plants and algae enzyme systems -- 1.12. Enzyme safety -- 1.13. Enzyme structure determination -- 1.14. Enzyme engineering and design -- 1.15. Enzymes in medicine and healthcare -- 1.16. Enzymes in bioremediation -- 1.17. Enzymes in agriculture and crop production -- 1.18. Enzymes in waste management8 a2. Technologies and procedures involved in enzyme production -- 2.1. Introduction -- 2.2. Enzyme production technology -- 2.3. Procedures involved in enzyme production -- 2.4. Recombinant proteins from algae -- 2.5. Enzyme immobilization techniques -- 2.6. Enzyme engineering for enhanced stability and activity -- 2.7. Upstream process intensification -- 2.8. Enzyme production from extreme environments -- 2.9. Downstream process intensification  aFull-text restricted to subscribers or individual document purchasers.3 aThis book offers a detailed examination of biotransformation and enzymes, focusing on their crucial roles in biology and biotechnology. It is intended for students, researchers, and professionals who are interested in understanding the biochemical processes by which organisms metabolize various compounds and how enzymes facilitate these processes. The book's primary aim is to provide a clear connection between theoretical concepts and their practical applications, showcasing biotransformation as an essential tool for developing sustainable solutions in pharmaceuticals, environmental management, and industrial practices. It comprehensively covers various biotransformation reactions, highlighting their importance in producing valuable products, detoxifying substances, and minimizing waste.  aScientists, researchers and practitioners in pharmaceutical biotechnology, biotechnology and biopharmaceuticals.  aAlso available in print.  aMode of access: World Wide Web.  aSystem requirements: Adobe Acrobat Reader, EPUB reader, or Kindle reader.  aAhmed Al-Harrasi is a professor of organic chemistry and the vice chancellor for graduate studies, research and external relations at the University of Nizwa. He obtained his BSc in Chemistry from SQU and his MSc and PhD in Organic Chemistry from Free University of Berlin as a DAAD-fellow. Then he received the Fulbright award in 2008 for postdoctoral research in Chemical Biology from Cornell University. He is a founder and chair of the Natural and Medical Sciences Research Center. He is a member of the Scientific Council of UNESCO. He was named on the list of top 2% Scientists for the last three years. He has authored over 800 scientific papers and more than 20 books and book chapters. He received the Order of Royal Commendation from His Majesty, The Sultan of Oman as an outstanding Omani individual for his remarkable contribution and active role in research. Saurabh Bhatia is an Associate Professor within the Natural and Medical Sciences Research Centre at the University of Nizwa, Oman. He has published 79 referred journal articles and written 94 book chapters. Dr. Bhatia has also authored 10 books and is the Associate Editor on four international journals. Ajmal Khan is currently working as an Associate Professor in Natural and Medical Sciences Research Centre at the University of Nizwa, Oman. Dr. Khan published more than 450 articles in international peer review journals with impact factor of more than 2000 and citation more than 9000. Besides this, he has published two US patents, and three books and 13 books chapters. Dr. Khan is Associate Editor for four journals and on the editorial board of three international journals.  aTitle from PDF title page (viewed on October 3, 2024).  aPharmaceutical biotechnology.965164  aPharmaceutical technology.  aBioengineering.965166  aBiotechnology.96516212aTechnology, Pharmaceutical.22aBiotechnology.965162 7aBiotechnology.2bicssc965162 7aMEDICAL / Biotechnology.2bisacsh9638911 aBhatia, Saurabh,eauthor.9969911 aKhan, Ajmalc(Ph. D. in biochemistry),eauthor.9969922 aInstitute of Physics (Great Britain),epublisher.917702 8iPrint version:z9780750353854z9780750353885 0aIOP (Series).pRelease 24.  aIOP ebooks.p2024 collection.4 uhttps://iopscience.iop.org/book/mono/978-0-7503-5387-8  cE-Books  c68479d68479