08416nam a2200865 i 45000010014000000030004000140050017000180060019000350070015000540080041000690200025001100200024001350200025001590200027001840240035002110350025002460350022002710400040002930500026003330600024003590720015003830720023003981000029004212400055004502450105005052640098006103000071007083360021007793370026008003380032008264900027008584900071008854900034009565000076009905000043010665040041011095050213011505050252013635050468016155050080020835050364021635050350025275050126028775050344030035050445033475050230037925050289040225050184043115050149044955050435046445060075050795200806051545210182059605300029061425380036061715380078062075450587062855880058068726500018069306500018069486500030069666500018069966500027070146500020070416500018070616500052070796500067071317000053071987100054072517760049073058300031073548300072073858300034074578560059074919780750362092IOP20251030124835.0m    eo  d        cr cn |||m|||a240801s2024    enka   fob    000 0 eng d  a9780750362092qebook  a9780750362085qmobi  z9780750362078qprint  z9780750362108qmyPrint7 a10.1088/978-0-7503-6209-22doi  a(CaBNVSL)thg00083965  a(OCoLC)1451139882  aCaBNVSLbengerdacCaBNVSLdCaBNVSL 4aRC271.R3bJ667 2024eb 4aWN 250bJ76p 2024eb 7aMF2bicssc 7aMED0800002bisacsh1 aJones, Bleddyn,eauthor.1 aPractical radiobiology for proton therapy planning1 aQuantitative radiobiology for proton therapy /cBleddyn Jones ; with contribution from Joshua Moore. 1aBristol [England] (Temple Circus, Temple Way, Bristol BS1 6HG, UK) :bIOP Publishing,c[2024]  a1 online resource (various pagings) :billustrations (some color).  atext2rdacontent  aelectronic2isbdmedia  aonline resource2rdacarrier1 a[IOP release $release]1 aIPEM-IOP series in physics and engineering in medicine and biology1 aIOP ebooks. [2024 collection]  aRevised edition of: Practical radiobiology for proton therapy planning.  a"Version: 20240701"--Title page verso.  aIncludes bibliographical references.  a1. Particle physics for biological interactions -- 1.1. Physical beam parameters, essential dosimetry and reference (or control) radiation requirements for RBE studies -- 1.2. Physics interacting with biology8 a2. The essential radiobiology background -- 2.1. Introduction -- 2.2. Background and models -- 2.3. The [alpha]/[beta] ratio and its choice for modelling particle therapies -- 2.4. The design of experiments for RBE determination and other purposes8 a3. Medical and surgical considerations that influence radiation tolerances, including interpretation of clinical trials -- 3.1. Introduction -- 3.2. Surgery -- 3.3. Cytotoxic chemotherapies -- 3.4. Age and other medical conditions -- 3.5. Reductions in prescribed dose -- 3.6. Interpretation of the case histories and literature -- 3.7. Clinical trials -- 3.8. Ethical issues -- 3.9. Mixed end points -- 3.10. The importance of follow-up -- 3.11. Publication bias8 a4. Treatment planning and further medical perspectives -- 4.1. Introduction8 a5. Historical development of radiotherapy : what was learned from fast neutrons including their linkage with proton relative biological effect -- 5.1. Introduction -- 5.2. A brief synopsis -- 5.3. Neutron therapy -- 5.4. More recent developments based on neutron studies -- 5.5. Estimation of neutron RBE from neutron energy -- 5.6. Some important conclusions8 a6. Fractionation modelling -- 6.1. Introduction and background radiobiology -- 6.2. A brief history of fractionation -- 6.3. Modelling of fractionation -- 6.4. The use of the linear quadratic model with large fraction sizes -- 6.5. Optimisation of fractionation using calculus methods -- 6.6. Other contributions to fractionation -- 6.7. Summary8 a7. The scientific case for using a variable proton RBE rather than a constant RBE -- 7.1. Introduction -- 7.2. Discussion8 a8. A general RBE linear energy-efficiency model for protons and light ions -- 8.1. Introduction -- 8.2. The available experimental data and its important limitations -- 8.3. Description of the Z-specific model -- 8.4. The graphical results -- 8.5. Further investigations : properties of LETU -- 8.6. Conclusions and what remains to be done8 a9. Inclusion of the energy-efficiency LET and RBE model in proton therapy -- 9.1. Introduction -- 9.2. RBE uncertainties -- 9.3. Description of the quantitative model -- 9.4. RBE graphical examples -- 9.5. Some comparisons with experimental data sets -- 9.6. Two clinical examples where PBT could be sub-optimal -- 9.7. Prediction of tumour response from the RBE increment -- 9.8. Intensification of dose rates -- 9.9. Concluding discussion8 a10. Proton therapy risk assessment using small increments in RBE in the central nervous system and estimation of remission times -- 10.1. Introduction -- 10.2. Methods -- 10.3. Results -- 10.4. Discussion -- 10.5. Conclusions8 a11. Radiobiological interpretation of the finding of RBE changes within similar SOBPs placed at superficial and deep locations in passively scattered beams but not in scanned pencil beams -- 11.1. Introduction -- 11.2. Methods -- 11.3. Results -- 11.4. Discussion -- 11.5. Conclusions8 a12. Particle therapy dose-time compensations in unintended interruptions and re-treatments -- 12.1. Introduction -- 12.2. Unintended treatment interruptions -- 12.3. Re-treatments8 a13. Errors of Bragg peak positioning and their radio-biological correction -- 13.1. Introduction -- 13.2. Model description -- 13.3. Conclusions8 a14. What remains to be done : including FLASH dose rates and conclusions -- 14.1. Introduction -- 14.2. Dose escalation where circumstances permit -- 14.3. Simultaneous 'sensitisation' effects by new therapies -- 14.4. Sensitivity analysis of the energy-efficiency model -- 14.5. What could be achieved in a single international laboratory dedicated to high-LET radiobiology -- 14.6. Some untested situations -- 14.7. Conclusions.  aFull-text restricted to subscribers or individual document purchasers.3 aThis book is an extension and major update of the author's previous work, titled Practical Radiobiology for Proton Therapy Planning (IOP Publishing 2018). The book describes the relative biological effectiveness (RBE) issues within proton therapy and advises on how to use a variable RBE within treatment planning and in dose prescription to improve the safety of proton and other forms on ion beam therapy. Decision-making advice is also provided for protocol breaches, retreatments, dose rate effects and risk assessment. This book is intended for those who already have basic knowledge of radiotherapy and radiobiology, although there is guidance through the fundamental principles for those who are 'discipline crossing'. Part of IPEM-IOP Series in Physics and Engineering in Medicine and Biology.  aMedical engineering, biomedical engineers, clinicians specializing in proton therapy and radiotherapy and radiobiology. Proton therapy centers and large regional cancer centers.  aAlso available in print.  aMode of access: World Wide Web.  aSystem requirements: Adobe Acrobat Reader, EPUB reader, or Kindle reader.  aBleddyn Jones, MD ScD FRCR, is an Emeritus Professor of Clinical Radiation Biology, University of Oxford. He has had over 40 years of interest and high impact research in neutron, proton and ion beam therapy and its associated radiobiology. He has made extensive contributions to the quantitative understanding of the relative biological effectiveness of particle therapy from the ballistic properties to their cellular and tissue effects. This includes many practical applications based on specific clinical situations, to guide proton therapy to safer and more effective outcomes.  aTitle from PDF title page (viewed on August 1, 2024).  aRadiobiology.  aRadiotherapy.  aProtonsxTherapeutic use.12aRadiobiology.12aRadiotherapyxmethods.12aProton Therapy.22aRadiotherapy. 7aPre-clinical medicine - basic sciences.2bicssc 7aMEDICAL / Radiology, Radiotherapy & Nuclear Medicine.2bisacsh1 aMoore, Joshuac(Ph. D. in mathematics),eauthor.2 aInstitute of Physics (Great Britain),epublisher. 8iPrint version:z9780750362078z9780750362108 0aIOP (Series).pRelease 24.  aIPEM-IOP series in physics and engineering in medicine and biology.  aIOP ebooks.p2024 collection.4 uhttps://iopscience.iop.org/book/mono/978-0-7503-6209-2