This book presents a comprehensive and updated overview of musculoskeletal injections with biologic and non-biologic injectable agents – a new trend of treatment in orthopaedics and sports medicine. This ESSKA book incorporates internal ongoing debates fostered by ESSKA U45 Committee and ESSKA’s Orthobiologics Initiative (ORBIT), which enroll a broad international group of dedicated clinicians and researchers. The topics covered mirror this fast evolving field which ranges from basic science knowledge to treatment options in sports traumatology. Renowned experts in the field examine and critically discuss each aspect, including existing controversies concerning indications and applications as well as the choice between biologic and non-biologic injections. Clear practical indications, subdivided by anatomical region and supported by a wealth of intra-procedural images, are aimed to support young surgeons in the application of musculoskeletal injections. Written by an international panel of clinicians and researchers, active in the field of orthobiology and sports medicine, this manual is an invaluable reference tool for all those involved in injectional therapies and sports traumatology.