Evolutionary Analysis of Alloy Specifications with an Adaptive Fitness Function -- Higher Fault Detection Through Novel Density Estimators in Unit Test Generation -- Many Independent Objective Estimation of Distribution Search for Android Testing -- SSBSE Summary of Adaptive Search based Repair of Deep Neural Networks -- SSBSE Summary of EvoCLINICAL Evolving Cyber cyber Digital Twin with Active Transfer Learning for Automated Cancer Registry System -- Iterative Refactoring of Real World Open Source Programs with Large Language Models -- Approximating Stochastic Quantum Noise through Genetic Programming -- Fuzzing Based Differential Testing For Quantum Simulators -- GreenStableYolo Optimizing Inference Time and Image Quality of Text to Image Generation -- Danger is My Middle Lane Simulations From Real World Dangerous Roads.

This book constitutes the refereed proceedings of the 16th International Symposium on Search-Based Software Engineering, SSBSE 2024, held in Porto de Galinhas, Brazil, during July 2024. The 8 papers included in these proceedings were carefully reviewed and selected from 19 submissions. The papers deal with various aspects and applications of search-based software engineering, focusing on engineering challenges and the application of automated approaches and optimization techniques from AI and machine learning research. .