Alpha Cell Contribution to Glucose Homeostasis -- Delta Cell Contribution to Glucose Homeostasis -- Islet Cell Plasticity Including Beta-Cell Dedifferentiation—Combined with Beta-Cell Heterogeneity -- Epigenetic Regulation of Pancreas Development and Function -- Beta-Cell Differentiation in vitro -- Endocrine Pancreas Regeneration -- Ductal Cell Development -- Relationship Between Beta-Cell Function and Beta-Cell Proliferation -- Maternal and Paternal Environmental Impacts on Beta-Cell Development -- Beyond Sugar: How Fat and Protein Contribute to the Regulation of Insulin Secretion -- Channels Involved in Regulating Insulin Secretion.

This book reviews recent advances in pancreatic endocrine and exocrine tissue development, function and regeneration. It provides a comprehensive overview on different aspects of beta-cell biology, including heterogeneity of function and gene expression and function, epigenetics, RNA and protein expression contributions to beta-cell specification and cell-fate maintenance. Furthermore, it covers recent progress in differentiating functional islets in vivo, environmental impacts on beta-cell development and function, and communications between various islet endocrine cells and how they contribute to the regulation of blood glucose homeostasis. The book provides a comprehensive resource for understanding the various compartments of the pancreas and is aimed at pancreas, beta-cell biology, and diabetes researchers.