Definition of irritable bowel syndrome -- The epidemiology of irritable bowel syndrome -- Part II. Pathophysiology -- Neurogastroenterology - Brain-Gut Axis, Stress and Psychological Factors -- Neuro-gastroenterology - Neurotransmitter, endocrine substance and motility -- Role of microbiota in the pathophysiology of irritable bowel syndrome -- Mucosal inflammation and visceral hypersensitivity in irritable bowel syndrome -- Genetic factors -- Part III. Diagnosis -- Diagnostic algorithm for IBS -- Differential diagnosis -- Comorbiditie -- Part IV. Treatment -- Pharmacotherapy for IBS-D -- Pharmacotherapy for irritable bowel syndrome with constipation -- GI motility modifier, bulking polymer and Herbal medicine -- Antidepressant, anxiolytics and psychotherapy -- Diet and behavioral modification for irritable bowel syndrome -- Probiotics and antibiotics -- Part V. Recent special topics -- Fecal Microbiota Transplantation for Treatment of Irritable Bowel Syndrome -- Clinical study design and evaluation of the efficacy in the treatment.

This edited book brings together 5 general themes of irritable bowel syndrome (IBS), presenting the latest information on the epidemiology, pathophysiology, diagnosis, treatment and a number of current topics. IBS is a functional bowel disorder associated with chromic abdominal pain and altered bowel habits without identifiable organic etiology, however, to date there is no known, agreed-upon disease mechanism. This book offers insights into the various factors potentially contributing to the symptoms, and provides data on the various globally recognized strategies, including novel pharmacological treatment agents. It also discusses geographical differences and region-specific factors such as medical systems, life styles, dietary habits, gut microbiota, social stress, and genetics. The book promotes further exploration of the disease by offering a comprehensive bibliography for each chapter. It is a valuable and thought-provoking resource for clinicians, researchers, residents and PIs who are interested in the latest basic and clinical research on IBS.