Section 1: Pre-Procedural Assessment -- Epidemiology: Atrial fibrillation, anticoagulation and stroke -- Current indications for left atrial appendage closure -- Anatomy of the left atrial appendage -- Pre-procedural planning for left atrial appendage closure: transesophageal echocardiography -- Pre-procedural planning for left atrial appendage closure: Cardiac computed tomography -- Pre-procedural planning for left atrial appendage closure: Cardiac Magnetic Resonance -- Section 2: Procedural Approach -- Same-day discharge for left atrial appendage closure -- Transseptal puncture: Best practice techniques -- Echocardiographic imaging guidance for left atrial appendage closure: transesophageal echocardiography (TEE) -- Echocardiographic imaging guidance for left atrial appendage closure: intra-cardiac echocardiography (ICE) -- Computed tomography-fluoro fusion guidance for left atrial appendage closure -- The WATCHMAN FLX left atrial appendage closure device: technical considerations and procedural approach -- The AMULET left atrial appendage closure device: technical considerations and procedural approach -- Novel percutaneous left atrial appendage closure devices -- Concomitant left atrial appendage closure & catheter ablation for atrial fibrillation -- Venous vascular closure devices -- Surgical treatment for left atrial appendage closure -- Section 3: Post-Procedural Management -- Post-procedural complications and management -- Post-procedural antiplatelet and anticoagulant strategies -- Post-procedural imaging and device-related features management -- Current evidence for left atrial appendage closure -- Shared decision-making and comprehensive atrial fibrillation management -- Future perspectives for left atrial appendage closure: CHAMPION-AF and CATALYST clinical trials.

This book is the first authoritative and comprehensive manual dedicated to left atrial appendage closure (LAAC). It provides an up-to-date and highly illustrated synopsis of the pre-, post- and peri-procedural approach for a state of the art contemporary approach for LAAC, and clinical applications of LAAC and its role in the treatment for Atrial Fibrillation. It relays to the reader a contemporary view of the emerging interplay between LAAO and atrial fibrillation. In addition, this manual discusses the clinical implications and therapeutic targets of LAAC in atrial fibrillation and increased risk for bleeding. A Contemporary Manual of Left Atrial Appendage Closure is an essential resource for physicians, residents, fellows, and medical students in cardiology, internal medicine, primary care, and health promotion and disease prevention.