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040 _aEBZ
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015 _aGBC321757
_2bnb
016 7 _a020941586
_2Uk
020 _a9781003288411
_qelectronic book
020 _a1003288413
_qelectronic book
020 _a9781000859010
_qelectronic book
020 _a1000859010
_qelectronic book
020 _a9781000859058
_qelectronic book
020 _a1000859053
_qelectronic book
020 _z9781032259277
_qhardcover
020 _z9781032264615
_qpaperback
024 3 _a9781003288411
024 7 _a10.1201/9781003288411
_2doi
037 _a9781003288411
_bTaylor & Francis
042 _apcc
050 0 4 _aRM301.25
_b.Z44 2023
072 7 _aSCI
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072 7 _aTEC
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072 7 _aMED
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072 7 _aTD
_2bicssc
049 _aMAIN
100 1 _aZhao, Wenyi
_c(Chemist),
_eauthor.
_964803
245 1 0 _aHandbook for chemical process research and development /
_cauthored by Wenyi Zhao, Senior Research Scientist, Jacobus Pharmaceutical Company, Princeton.
246 3 0 _aChemical process research and development
250 _aSecond edition.
264 1 _aBoca Raton, FL :
_bCRC Press,
_c2023.
264 4 _c©2023
300 _a1 online resource (xxxix, 825 pages) :
_billustrations
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
341 0 _atextual
_2sapdv
_3EBSCOhost
504 _aIncludes bibliographical references and index.
505 0 _a1. Reaction solvent selection2. Reagent selection3. Various reagent surrogates4. Modes of reagent addition -control of impurity formation5. Process optimization with additives6. Process optimization of catalytic reactions7. Process optimization of problematic reactions8. Hazards of oxidation and reduction reactions9. Other hazardous reactions10. Hazardous reagents11. Grignard reagent and related reactions12. Challenging reaction intermediates13. Protecting groups14. Telescope approach15. Design of new synthetic route16. Stereochemistry17. Various quenching strategies18. Various isolation and purification strategies19. Methods for residual metal removal20. Methods for impurity removal21. Pharmaceutical salts22. Solid form
520 _a"This fully updated second edition reflects the significant changes in process chemistry since the first edition and includes more common process issues such as safety, cost, robustness, and environmental impact. Some areas have made notable progress such as process safety, stereochemistry, new reagents and reagent surrogates. Forty years ago there were few process research and development activities in the pharmaceutical industry, partly due to the simplicity of drug molecules. With increasing structural complexity especially the introduction of chiral centers into drug molecules and stricter regulations, process R&D has become one of the critical departments for pharmaceutical companies"--
_cProvided by publisher.
532 0 _3EBSCOhost
_a"EBSCO evaluates our products based on the Web Content Accessibility Guidelines (WCAG) and the related Section 508 and EN 301 549 regulations in the US and EU. Most EBSCO products are substantially conformant with WCAG 2.2 level AA." Source: https://connect.ebsco.com/s/article/EBSCO-VPATs?language=en_US. Last accessed April 22, 2025.
588 _aDescription based on online resource; title from digital title page (viewed on October 20, 2023).
650 0 _aDrugs
_xResearch.
_964804
650 0 _aDrugs
_xResearch
_xMethodology.
_964805
650 0 _aPharmaceutical industry.
_964806
650 2 _aDrug Industry
_964807
650 7 _aSCIENCE / Chemistry / Industrial & Technical
_2bisacsh
_964808
650 7 _aTECHNOLOGY / Engineering / Chemical & Biochemical
_2bisacsh
_963924
650 7 _aMEDICAL / Pharmacology
_2bisacsh
_964250
758 _ihas work:
_aHandbook for chemical process research and development (Text)
_1https://id.oclc.org/worldcat/entity/E39PCFvmYfJx7cXVTtwDJWmprm
_4https://id.oclc.org/worldcat/ontology/hasWork
776 0 8 _iPrint version:
_aZhao, Wenyi
_tHandbook for chemical process research and development
_bSecond edition.
_dBoca Raton, FL : CRC Press, [2023]
_z9781032259277
_w(DLC) 2022047640
856 4 0 _3EBSCOhost
_uhttps://search.ebscohost.com/login.aspx?direct=true&scope=site&db=nlebk&db=nlabk&AN=3547971
938 _aAskews and Holts Library Services
_bASKH
_nAH40838475
938 _aEBSCOhost
_bEBSC
_n3547971
994 _a92
_bN$T
999 _c56069
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