| 000 | 03478nam a22005175i 4500 | ||
|---|---|---|---|
| 001 | 978-3-031-51346-6 | ||
| 003 | DE-He213 | ||
| 005 | 20251030110914.0 | ||
| 007 | cr nn 008mamaa | ||
| 008 | 240104s2024 sz | s |||| 0|eng d | ||
| 020 |
_a9783031513466 _9978-3-031-51346-6 |
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_a10.1007/978-3-031-51346-6 _2doi |
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| 050 | 4 | _aRM300-666 | |
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_aMMG _2bicssc |
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_aMED071000 _2bisacsh |
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_aMKG _2thema |
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_aAnion Channels and Transporters _h[electronic resource] / _cedited by Christoph Fahlke. |
| 250 | _a1st ed. 2024. | ||
| 264 | 1 |
_aCham : _bSpringer International Publishing : _bImprint: Springer, _c2024. |
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| 300 |
_aX, 362 p. 100 illus., 30 illus. in color. _bonline resource. |
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| 336 |
_atext _btxt _2rdacontent |
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| 337 |
_acomputer _bc _2rdamedia |
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| 338 |
_aonline resource _bcr _2rdacarrier |
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| 347 |
_atext file _bPDF _2rda |
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| 490 | 1 |
_aHandbook of Experimental Pharmacology, _x1865-0325 ; _v283 |
|
| 505 | 0 | _aPreface -- Muscle chloride channels -- Adrenal anion channels - new roles in zona glomerulosa physiology and in the pathophysiology of primary aldosteronism -- ClC-K Kidney Chloride Channels : from structure to pathology -- Biophysical and pharmacological insights to CLC chloride channels and Transporters -- Function and regulation of the calcium-activated chloride channel anoctamin 1 -- Structure and function of calcium-activated chloride channels and scramblases in TMEM16 family -- Structural basis for anion-selective Cys-loop receptor signal transduction and modulation -- Physiological functions of the volume regulated anion channel VRAC/LRRC8 and the proton-activated chloride channel PAC/TMEM206 -- CFTR modulators: from mechanism to targeted therapeutics -- Structure, physiology, and pharmacology of chloride-dependent cation cotransporters -- SLC26 Anion Transporters -- Pharmacology of Na-dependent transporters of inorganic phosphate -- Simulation of fluoride anions in CLC proteins: from potent inhibition to selective transport. | |
| 520 | _aThis book provides an overview on recent progress in anion channels and transporters. It covers multiple scales of analysis ranging from studying the molecular basis of function at atomic resolution to cellular consequences to channel/transporter dysfunction and approaches to correct such processes by pharmacological intervention. Similar anion channels and transporters are expressed in multiple tissues – often fulfilling similar cellular tasks, but also clearly distinct functions. The aim is to combine work on multiple cell and organ systems. | ||
| 650 | 0 |
_aPharmacology. _967844 |
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| 650 | 0 |
_aHuman physiology. _969239 |
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| 650 | 1 | 4 |
_aPharmacology. _967844 |
| 650 | 2 | 4 |
_aHuman Physiology. _969240 |
| 700 | 1 |
_aFahlke, Christoph. _eeditor. _4edt _4http://id.loc.gov/vocabulary/relators/edt _969241 |
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| 710 | 2 | _aSpringerLink (Online service) | |
| 773 | 0 | _tSpringer Nature eBook | |
| 776 | 0 | 8 |
_iPrinted edition: _z9783031513459 |
| 776 | 0 | 8 |
_iPrinted edition: _z9783031513473 |
| 776 | 0 | 8 |
_iPrinted edition: _z9783031513480 |
| 830 | 0 |
_aHandbook of Experimental Pharmacology, _x1865-0325 ; _v283 _969242 |
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| 856 | 4 | 0 | _uhttps://doi.org/10.1007/978-3-031-51346-6 |
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