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020 _a9789819994007
_9978-981-99-9400-7
024 7 _a10.1007/978-981-99-9400-7
_2doi
050 4 _aTA418.95-455.2
050 4 _aQP620-625
072 7 _aTGM
_2bicssc
072 7 _aTEC021000
_2bisacsh
072 7 _aTGML
_2thema
100 1 _aMori, Keita.
_eauthor.
_4aut
_4http://id.loc.gov/vocabulary/relators/aut
_970553
245 1 0 _aMetal-Responsive Base Pair Switching of Ligand-type Uracil Nucleobases
_h[electronic resource] /
_cby Keita Mori.
250 _a1st ed. 2024.
264 1 _aSingapore :
_bSpringer Nature Singapore :
_bImprint: Springer,
_c2024.
300 _aXVII, 125 p. 111 illus., 101 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aSpringer Theses, Recognizing Outstanding Ph.D. Research,
_x2190-5061
505 0 _a1. General introduction -- 2. Metal-responsive DNA strand displacement reactions driven by base pair switching of 5-hydroxyuracil nucleobases -- 3. Metal-dependent base pair switching of N,N,-dicarboxymethyl-5-aminouracil nucleosides -- 4. Metal-responsive DNA tweezers driven by base pair switching of 5-hydroxyuracil nucleobases -- 5. Conclusion and perspectives.
520 _aIn this thesis, the author proposes "metal-responsive base pair switching" of ligand-modified nucleobases as a novel tool for stimuli-responsive control of DNA assemblies. It is written to demonstrate broad applicability of the base pair switching in dynamic DNA nanotechnology and inspire researchers to use this technique. Based on specific interactions between ligand-type nucleobases and target metal ions, in this volume, DNA hybridization was dynamically controlled through strand displacement reactions. The base pair switching was further applied to develop metal-dependent DNA molecular machines. This novel strategy for stimuli-responsive regulation of DNA assemblies will greatly expand the scope of dynamic DNA nanotechnology. This volume uniquely features importance of elaborate molecular design based on chemistry for imparting stimuli responsiveness to DNA assemblies.
650 0 _aBiomaterials.
650 0 _aNucleic acids.
_970554
650 0 _aCoordination compounds.
_970555
650 0 _aNanotechnology.
650 0 _aSelf-assembly (Chemistry).
_970556
650 1 4 _aNucleic Acid.
_970557
650 2 4 _aCoordination Chemistry.
_970558
650 2 4 _aNanotechnology.
650 2 4 _aSelf-assembly.
_970559
710 2 _aSpringerLink (Online service)
773 0 _tSpringer Nature eBook
776 0 8 _iPrinted edition:
_z9789819993994
776 0 8 _iPrinted edition:
_z9789819994014
776 0 8 _iPrinted edition:
_z9789819994021
830 0 _aSpringer Theses, Recognizing Outstanding Ph.D. Research,
_x2190-5061
_966370
856 4 0 _uhttps://doi.org/10.1007/978-981-99-9400-7
912 _aZDB-2-CMS
912 _aZDB-2-SXC
999 _c57474
_d57474