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020 _a9783031497445
_9978-3-031-49744-5
024 7 _a10.1007/978-3-031-49744-5
_2doi
050 4 _aQP361-430
050 4 _aQP90.2
072 7 _aPSAN
_2bicssc
072 7 _aSCI089000
_2bisacsh
072 7 _aPSAN
_2thema
245 1 0 _aRegenerative Medicine and Brain Repair
_h[electronic resource] /
_cedited by Philip V. Peplow, Bridget Martinez, Thomas A. Gennarelli.
250 _a1st ed. 2024.
264 1 _aCham :
_bSpringer International Publishing :
_bImprint: Springer,
_c2024.
300 _aXIV, 343 p. 29 illus., 28 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aStem Cell Biology and Regenerative Medicine,
_x2196-8993 ;
_v75
505 0 _aInitiating and Facilitating Brain Repair: Factors, Principles, and Mechanisms -- Strategies to Upgrade the Stem Cell Application for Brain Transplantation -- Neural Stem Cell Intervention in Traumatic Brain Injury -- Neurotrophic Factors in Parkinson’s Disease: Clinical Trials -- Emerging Nanotechnology for the Treatment and Diagnosis of Parkinson’s Disease (PD) and Alzheimer’s Disease (AD) -- Poly(Butyl Cyanoacrylate) Nanoparticles deliver β-Nerve Growth Factor to the Brain after Traumatic Brain Injury -- The Significance of Biomaterials in Stem Cell-Based Regenerative Medicine -- Endogenous in situ Tissue Regeneration using Inductive Bioscaffolds after Acute Brain Injury -- Alginate Nanofibre Scaffolds for Amyotrophic Lateral Sclerosis -- Developing High-Fidelity in vitro Models of Traumatic Brain Injury to Test Therapeutic Biomaterials -- Challenges and Future Perspectives of Using Bioactive Scaffolds in Brain Repair.
520 _aThis book presents the latest knowledge, trends, and advances in cell transplantation and innovations in developing microspheres, 3D biomaterial constructs to enhance transfer, and cell survival to specific regions of the brain. Neurodegenerative diseases and brain injury are increasing. Medications currently only temporarily reduce some of the symptoms but do not cure or delay progression of the disease. Development of effective treatments dramatically improves the independent living and quality of life of patients. Cell transplantation strategies offer an approach to facilitating brain repair, but efficacy is often limited by low in vivo survival rates of cells that are injected in suspension. Transplanting cells that are attached to or encapsulated within a biomaterial construct has the advantage of maintaining cell-cell and cell-material interactions and improving cell survival in vivo. Biomaterials that have been used in preclinical studies to assist with in vivo cell transfer and survival include heparin-chitosan microspheres, poly(lactic-co-glycolic acid) microspheres, RADA 16 microspheres, poly(desaminotyrosyl tyrosine ethyl ester carbonate) microscale scaffolds, carbon nanotubes, collagen-chitosan scaffolds, poly(L-lactic acid) scaffolds, agarose hydrogels, gelatin methacrylate hydrogels, and agarose micro-columns with an extracellular matrix interior. Incorporating growth factors (e.g., glial-derived neurotrophic factor, neurotrophin 3) into the biomaterial constructs increased cell survival and incorporation into the host tissue. International experts in the fields of both experimental and clinical neurological research contribute chapters to this book and discuss the latest achievements in cell transplantation and matrix-assisted cell transfer/survival technologies for diseases such as Alzheimer’s disease, Parkinson’s disease, and brain injuries such as stroke and traumatic brain injury. It is envisaged that research findings in experimental animal models of Alzheimer’s disease, Parkinson’s disease, traumatic brain injury, and stroke promote clinical trials using biomaterial-assisted transfer of cells.
650 0 _aNervous system
_xRegeneration.
_971547
650 0 _aRegenerative medicine.
_967458
650 0 _aStem cells.
_967435
650 0 _aBiomedical engineering.
650 0 _aBiomaterials.
650 1 4 _aRegeneration and Repair in the Nervous System.
_971548
650 2 4 _aRegenerative Medicine and Tissue Engineering.
_967459
650 2 4 _aStem Cell Biology.
_967439
650 2 4 _aBiomedical Engineering and Bioengineering.
650 2 4 _aBiomaterials.
700 1 _aPeplow, Philip V.
_eeditor.
_4edt
_4http://id.loc.gov/vocabulary/relators/edt
_971549
700 1 _aMartinez, Bridget.
_eeditor.
_4edt
_4http://id.loc.gov/vocabulary/relators/edt
_971550
700 1 _aGennarelli, Thomas A.
_eeditor.
_4edt
_4http://id.loc.gov/vocabulary/relators/edt
_971551
710 2 _aSpringerLink (Online service)
773 0 _tSpringer Nature eBook
776 0 8 _iPrinted edition:
_z9783031497438
776 0 8 _iPrinted edition:
_z9783031497452
776 0 8 _iPrinted edition:
_z9783031497469
830 0 _aStem Cell Biology and Regenerative Medicine,
_x2196-8993 ;
_v75
_971552
856 4 0 _uhttps://doi.org/10.1007/978-3-031-49744-5
912 _aZDB-2-SBL
912 _aZDB-2-SXB
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