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020 _a9783031424229
_9978-3-031-42422-9
024 7 _a10.1007/978-3-031-42422-9
_2doi
050 4 _aQD241-441
072 7 _aPNN
_2bicssc
072 7 _aSCI013040
_2bisacsh
072 7 _aPNN
_2thema
245 1 0 _aNeurotrophic Natural Products
_h[electronic resource] /
_cedited by A. Douglas Kinghorn, Heinz Falk, Simon Gibbons, Yoshinori Asakawa, Ji-Kai Liu, Verena M. Dirsch.
250 _a1st ed. 2024.
264 1 _aCham :
_bSpringer Nature Switzerland :
_bImprint: Springer,
_c2024.
300 _aIX, 473 p. 297 illus., 54 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aProgress in the Chemistry of Organic Natural Products,
_x2192-4309 ;
_v123
505 0 _a1. Neurotrophins and Screening Models to Search for Neurotrophic Natural Products -- 2. Fatty Acid-Related Compounds with Neurotrophic Activity -- 3. Terpenes Possessing Neurotrophic Activity -- 4. Aromatic Compounds Possessing Neurotrophic Activity -- 5. Alkaloids Possessing Neurotrophic Properties -- 6. Closing Remarks.
520 _aThis book deals with neurotrophins (NGF, BDNF, NT3, NT4), which can decrease cell death, induce differentiation, as well as sustain the structure and function of neurons. This makes neurotrophins potential therapeutic agents for the treatment of neurodegenerative disorders. However, these proteins have so far been ineffective in clinical trials mostly because they cannot pass the blood-brain barrier owing to their high-molecular weights. Consequently, small molecules that mimic neurotrophins and stimulate the synthesis of endogenous neurotrophins or enhance their neurotrophic actions are expected to be promising alternatives. Small-molecule natural products, which have been used in dietary functional foods or in traditional medicine over the course of human history, have potential to be developed as new therapeutic agents against neurodegenerative conditions such as Alzheimer’s disease. In this book, the authors introduce a variety of natural products possessing neurotrophic properties such as neurogenesis, neurite outgrowth promotion (neuritogenesis), and neuroprotection and focus on the chemistry and biology of several neurotrophic natural products.
650 0 _aNatural products.
650 0 _aChemistry.
650 0 _aNeurochemistry.
_972462
650 0 _aChemistry, Organic.
_965325
650 1 4 _aNatural Products.
650 2 4 _aChemical Synthesis.
_968822
650 2 4 _aNeurochemistry.
_972462
650 2 4 _aOrganic Chemistry.
_965327
700 1 _aKinghorn, A. Douglas.
_eeditor.
_0(orcid)0000-0002-6647-8707
_1https://orcid.org/0000-0002-6647-8707
_4edt
_4http://id.loc.gov/vocabulary/relators/edt
_972463
700 1 _aFalk, Heinz.
_eeditor.
_4edt
_4http://id.loc.gov/vocabulary/relators/edt
_972464
700 1 _aGibbons, Simon.
_eeditor.
_0(orcid)0000-0003-1587-6809
_1https://orcid.org/0000-0003-1587-6809
_4edt
_4http://id.loc.gov/vocabulary/relators/edt
_972465
700 1 _aAsakawa, Yoshinori.
_eeditor.
_0(orcid)0000-0002-1847-412X
_1https://orcid.org/0000-0002-1847-412X
_4edt
_4http://id.loc.gov/vocabulary/relators/edt
_972466
700 1 _aLiu, Ji-Kai.
_eeditor.
_0(orcid)0000-0001-6279-7893
_1https://orcid.org/0000-0001-6279-7893
_4edt
_4http://id.loc.gov/vocabulary/relators/edt
_972467
700 1 _aDirsch, Verena M.
_eeditor.
_0(orcid)0000-0002-9261-5293
_1https://orcid.org/0000-0002-9261-5293
_4edt
_4http://id.loc.gov/vocabulary/relators/edt
_972468
710 2 _aSpringerLink (Online service)
773 0 _tSpringer Nature eBook
776 0 8 _iPrinted edition:
_z9783031424212
776 0 8 _iPrinted edition:
_z9783031424236
776 0 8 _iPrinted edition:
_z9783031424243
830 0 _aProgress in the Chemistry of Organic Natural Products,
_x2192-4309 ;
_v123
_972469
856 4 0 _uhttps://doi.org/10.1007/978-3-031-42422-9
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