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020 _a9783031390272
_9978-3-031-39027-2
024 7 _a10.1007/978-3-031-39027-2
_2doi
050 4 _aQH491-492
072 7 _aPSC
_2bicssc
072 7 _aSCI072000
_2bisacsh
072 7 _aPSC
_2thema
100 1 _aKondoh, Hisato.
_eauthor.
_4aut
_4http://id.loc.gov/vocabulary/relators/aut
_973445
245 1 0 _aMolecular Basis of Developmental and Stem Cell Regulation
_h[electronic resource] :
_bClassical Models Revised /
_cby Hisato Kondoh.
250 _a1st ed. 2024.
264 1 _aCham :
_bSpringer International Publishing :
_bImprint: Springer,
_c2024.
300 _aXII, 255 p. 109 illus., 108 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aResults and Problems in Cell Differentiation,
_x1861-0412 ;
_v72
505 0 _aPart I. Somatic Cell Development from the Epiblast -- Chapter 1. The Epiblast and Pluripotent Stem Cell Lines -- Chapter 2. Different Types of Pluripotent Stem Cells Represent Different Developmental Stages -- Chapter 3. Gastrulation: Its Principles and Variations -- Chapter 4. How the Brain Develops from the Epiblast: The Node Is Not an Organizer -- Part II -- New Conceptions of Developmental Regulations -- Chapter 5. Multiple Cell Lineages Give Rise to a Cell Type -- Chapter 6. Organ Regeneration without Relying on Regeneration-Dedicated Stem Cells -- Chapter 7. Reciprocal Interactions Between the Epithelium and Mesenchyme in Oorganogenesis.-Chapter 8. The Significance of Repressive Processes in Developmental Regulation -- Part III. Transcriptional Regulation of Development -- Chapter 9. Enhancer Arrays Regulating Developmental Genes: Sox2 Enhancers as a Paradigm -- Chapter 10. Enhancer Activation by Transcription Factors and Underlying Mechanisms -- Chapter 11. Molecular Basis of Cell Reprogramming into iPSCs with Exogenous Transcription Factors.
520 _aThis book provides a comprehensive overview of the molecular basis of developmental and stem cell regulation. It revisits some of the classical models of developmental biology and puts them in context with the findings of modern stem cell research and developmental biology. Biomedical research is embarking on a new era due to new tools, which are exemplified by stem cell technologies, single-cell transcriptome analysis, and live imaging at a single-cell resolution. Publications based on cutting-edge technologies do often not provide the readers with deep biological backgrounds. This causes the risk that precious data are reduced to highly specific descriptions without sufficient biological contexts. Contemporary developmental biology on the other hand as written in many textbooks, is to a significant extent based on conceptions backdated many decades ago, and is not necessarily supported by recent findings. Yet, the prevailing classical notions tend to mislead modern biomedical researches. This book not only presents current models for developmental processes but also reinterprets and re-evaluates classic observations, thus linking classical and modern worlds of developmental biology. Spanning from molecular mechanisms to highly embryological matters it provides a bridge between these different disciplines. Written for advanced students of developmental and stem cell biology, researchers and teaching scholars, this book provides a new road map to modern developmental biology and stem cell biology.
650 0 _aDevelopmental biology.
_967434
650 0 _aStem cells.
_967435
650 0 _aCell differentiation.
650 0 _aCytology.
_967436
650 0 _aDevelopmental genetics.
_973446
650 0 _aEmbryology.
_973447
650 1 4 _aDevelopmental Biology and Stem Cells.
_967438
650 2 4 _aStem Cell Biology.
_967439
650 2 4 _aCell Differentiation.
650 2 4 _aCell Biology.
_967440
650 2 4 _aDevelopmental Genetics.
_973448
650 2 4 _aEmbryology.
_973447
710 2 _aSpringerLink (Online service)
773 0 _tSpringer Nature eBook
776 0 8 _iPrinted edition:
_z9783031390265
776 0 8 _iPrinted edition:
_z9783031390289
776 0 8 _iPrinted edition:
_z9783031390296
830 0 _aResults and Problems in Cell Differentiation,
_x1861-0412 ;
_v72
_967443
856 4 0 _uhttps://doi.org/10.1007/978-3-031-39027-2
912 _aZDB-2-SBL
912 _aZDB-2-SXB
999 _c58479
_d58479